Indian Journal of Pharmacy and Pharmacology

Print ISSN: 2393-9079

Online ISSN: 2393-9087

CODEN : IJPPTK

Indian Journal of Pharmacy and Pharmacology (IJPP) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, research content, providing professional’s membership, and conducting conferences, seminars, and award programs. With more...

Article type

Original Article


Article page

47-52


Authors Details

Akash Sagar, Sarita Karole*, Anup K Chakraborty, Kavita R Loksh


Article Metrics


View Article As

 


Downlaod Files

   






Article statistics

Viewed: 390

PDF Downloaded: 871


Formulation, development and characterization of topical organogel of mometasone furoate for the treatment of skin disease


Original Article

Author Details : Akash Sagar, Sarita Karole*, Anup K Chakraborty, Kavita R Loksh

Volume : 9, Issue : 1, Year : 2022

Article Page : 47-52

https://doi.org/10.18231/j.ijpp.2022.009



Suggest article by email

Get Permission

Abstract

Background: Topical glucocorticoid formulations are widely used for effective treatment and control of a variety of dermatoses. Mometasone furoate is a medium potency, synthetic, non-fluorinated topical corticosteroid, indicated for the relief of inflammatory and pruritic manifestations of corticosteroid responsive dermatoses including psoriasis. The percutaneous absorption increases risk associated with systemic absorption of topically applied formulation. Controlled release of the drug to the skin could reduce the side effects while reducing percutaneous absorption. Organogels are semi-solid materials, in which an organic phase is immobilized by a three-dimensional network composed of self-organized system, forming the aqueous phase.
Aims & Objectives: The present study deals with the preparation and evaluation of a pluronic lecithin organogel gel containing mometasone furoate for transdermal delivery. Blank pluronic lecithin organogel were prepared using ricinoleic acid as the oil phase.
Formulation, Development and Characterization of Topical Organogel of Mometasone Furoate was carried out and evaluated for the treatment of Skin Disease. The absorption maxima of mometasone furoate were determined by running the spectrum of drug solution in double beam ultraviolet spectrophotometer (Labindia UV 3000+) using concentration range of 5-25?g/ml mometasone furoate in 7.4 phosphate buffers. The IR spectrum of sample drug and drug with excipients shows the peak values which are characteristics of the drug.
Results: The formulated gel formulation was evaluated with parameter appearance, consistency, drug content pH, viscosity, spreadability, in-vitro release test, washability, extrudability study and stability studies. FT-IR studies revealed no interaction between the drug and excipients. Selected organogels (F3) showed a drug content of 99.45±0.14% and drug release of 99.12 % in10 hrs.
Conclusion: The results suggest that the developed organogels formulation containing mometasone furoate can be of actual value for improving the clinical effectiveness in the treatment of psoriasis.


Keywords: Mometasone furoate, Organogels, Psoriasis, Ricinoleic acid, in­vitro release test


How to cite : Sagar A, Karole S, Chakraborty A K, Loksh K R, Formulation, development and characterization of topical organogel of mometasone furoate for the treatment of skin disease. Indian J Pharm Pharmacol 2022;9(1):47-52

This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.