Indian Journal of Pharmacy and Pharmacology

Print ISSN: 2393-9079

Online ISSN: 2393-9087

CODEN : IJPPTK

Indian Journal of Pharmacy and Pharmacology (IJPP) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, research content, providing professional’s membership, and conducting conferences, seminars, and award programs. With more...

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Original Article


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29-34


Authors Details

K L Senthil Kumar*, P D Gokulan , A Vasanthan, S Venkateswaran, H Santhosh, R Vinoth kumar, S Ragul


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Preparation and evaluation of matrix type of transdermal patches containing anti –diabetic drug


Original Article

Author Details : K L Senthil Kumar*, P D Gokulan , A Vasanthan, S Venkateswaran, H Santhosh, R Vinoth kumar, S Ragul

Volume : 9, Issue : 1, Year : 2022

Article Page : 29-34

https://doi.org/10.18231/j.ijpp.2022.006



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Abstract

The current research aims to formulate and evaluated medicated transdermal patches containing an anti-diabetic drug. A good penetration enhancer would improve drug delivery from various polymer-based transdermal patches. Transdermal patches of the matrix type are made. Using various PVP K30, MC ratios and solvent evaporation techniques. All prepared formulations were tested for weight variation, thickness, drug content, moisture content, moisture uptake, flatness, and in vitro drug release. Bath F3 was optimised formula from all formulation baths shows linear zero order release for 24 hours, with a cumulative percentage of drug diffusion of 87.35% from 4cm2 patches. It has been determined that polymer concentration. When the concentration of PVP K30 increases in the primary layer, the in – vitro diffusion rate increases, and when the concentration of PVP K30 decreases, the drug diffusion decreases. It allows for more controlled drug release from the patch.


Keywords: Glimepiride, matrix type transdermal patch, PVP K30, Methyl cellulose, in­vitro study, and etc


How to cite : Kumar K L S, Gokulan P D, Vasanthan A, Venkateswaran S, Santhosh H, Kumar R V, Ragul S, Preparation and evaluation of matrix type of transdermal patches containing anti –diabetic drug. Indian J Pharm Pharmacol 2022;9(1):29-34

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