Indian Journal of Pharmacy and Pharmacology

Print ISSN: 2393-9079

Online ISSN: 2393-9087

CODEN : IJPPTK

Indian Journal of Pharmacy and Pharmacology (IJPP) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, research content, providing professional’s membership, and conducting conferences, seminars, and award programs. With more...

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Original Article


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263-266


Authors Details

Debalina Sardar, Raja Chakraverty*, Pranabesh Chakraborty


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Evaluation of potential antidiabetic activity of abelmoschus esculentus and evidence of possible pharmacokinetic interaction with metformin


Original Article

Author Details : Debalina Sardar, Raja Chakraverty*, Pranabesh Chakraborty

Volume : 8, Issue : 4, Year : 2021

Article Page : 263-266

https://doi.org/10.18231/j.ijpp.2021.047



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Abstract

The study is aimed at the evaluation of potential activity of and possible interaction with metformin in animal Models of Diabetes Mellitus. Study objectives include study the anti-diabetic effect of for Diabetes Mellitus in animal models and also to study the effect of Abelmoschus esculentus with metformin and explore any interaction. Plant material was collected () followed by extraction of plant materials () Exudate collection of and activity test study was done (acute toxicity study, according to standard OECD guidelines) Experimental animals were divided into groups. Dosing was done for 28 days. Biochemical parameters were studied. Histopathology studies are done. Results showed that in this study administrations of Abelmoschus esculentus extract (2000mg/kg body weight) Metformin with extract (5mg/kg b.w. and 2000mg/kg body weight and Metformin 5mg/kg body weight decreased elevated blood glucose levels significantly from first to fourth week compared to diabetic control rats and showed minimal safety concerns.


Keywords: Abelmoschus esculentus, Metformin, Antagonism, Diabetes mellitus


How to cite : Sardar D, Chakraverty R, Chakraborty P, Evaluation of potential antidiabetic activity of abelmoschus esculentus and evidence of possible pharmacokinetic interaction with metformin. Indian J Pharm Pharmacol 2021;8(4):263-266

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