Indian Journal of Pharmacy and Pharmacology

Print ISSN: 2393-9079

Online ISSN: 2393-9087

CODEN : IJPPTK

Indian Journal of Pharmacy and Pharmacology (IJPP) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, research content, providing professional’s membership, and conducting conferences, seminars, and award programs. With more...

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Original Article


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74-77


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Ashok Agrawal*, Anita Mehta


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Vitamin D acts as independently from glucocorticoid receptor in animal model of asthma


Original Article

Author Details : Ashok Agrawal*, Anita Mehta

Volume : 8, Issue : 1, Year : 2021

Article Page : 74-77

https://doi.org/10.18231/j.ijpp.2021.012



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Abstract

Now a day most of the patients on long term therapy of glucocorticoid become insensitive to corticosteroids and addition of vitamin D to such patients may enhance to response to corticosteroids. Therefore, we investigated anti-inflammatory activity of vitamin D in presence of glucocorticoids receptor antagonist; mifepristone, to assess whether, vitamin D acts as dependent or independently from glucocorticoids receptor. Wistar albino rats were sensitized with ovalbumin (OVA) and, upon OVA challenge, developed
airway eosinophilia and neutrophilia. Administration of dextamethasone, vitamin D and combination of dextamethasone+vitamin D, and dextamethasone+vitamin D+mifepristone significantly (P<0>

Keywords: Asthma, Vitamin D, Mifepristone.


How to cite : Agrawal A , Mehta A , Vitamin D acts as independently from glucocorticoid receptor in animal model of asthma. Indian J Pharm Pharmacol 2021;8(1):74-77

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