Indian Journal of Pharmacy and Pharmacology

Print ISSN: 2393-9079

Online ISSN: 2393-9087

CODEN : IJPPTK

Indian Journal of Pharmacy and Pharmacology (IJPP) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, research content, providing professional’s membership, and conducting conferences, seminars, and award programs. With more...

Article type

Original Article


Article page

65-73


Authors Details

Manojkumar S Mahajan, Aman B Upaganlawar, Chandrashekhar D Upasani*


Article Metrics


View Article As

 


Downlaod Files

   






Article statistics

Viewed: 513

PDF Downloaded: 439


The effect of co-enzyme Q10 and N-acetylcysteine on biochemical parameters and oxidative stress in rats subjected to alloxan induced diabetic nephropathy


Original Article

Author Details : Manojkumar S Mahajan, Aman B Upaganlawar, Chandrashekhar D Upasani*

Volume : 8, Issue : 1, Year : 2021

Article Page : 65-73

https://doi.org/10.18231/j.ijpp.2021.011



Suggest article by email

Get Permission

Abstract

Introduction: Diabetic nephropathy (DN) has been recognized as the one of the microvascular chronic complications resulting from diabetes. Though, efforts have taken to develop effective therapies for attenuation of DN, involvement of the multiple pathogenetic mechanisms and underlying oxidative stress (OS) makes it difficult to choose optimum therapeutic agent.
Objective: The study is aimed at assessing the possible therapeutic effect of coenzyme Q10 (CoQ10) and N-acetylcysteine (NAC) individually or in combination on experimental DN in rats.
Materials and Methods: The study was performed on adult male Sprague Dawley rats (n = 50; 200–250 g). Rats were made diabetic by alloxan (130 mg/kg; i.p.). The non-diabetic rats were randomly assigned to control, CoQ10 (10 mg/kg, p.o.), NAC (300 mg/kg, p.o.), and CoQ10+ NAC group. Whereas diabetic rats were grouped as DN control, DN+ CoQ10, DN+ NAC and DN+ CoQ10 +NAC groups. CoQ10 and/or NAC were administered to the diabetic rats for 8 weeks after confirmation of the DN. Renal functions and tissue antioxidant parameters were estimated.
Results: Renal function tests and urinary proteins were significantly (p<0> Conclusion: The study provides valuable information supporting that treatment with combination of CoQ10 and NAC might prevent or delay the renal damage associated with DN and improves the antioxidant.

Keywords: Diabetic nephropathy, Coenzyme Q10, N-acetylcysteine, Oxidative stress, Alloxan.


How to cite : Mahajan M S , Upaganlawar A B , Upasani C D , The effect of co-enzyme Q10 and N-acetylcysteine on biochemical parameters and oxidative stress in rats subjected to alloxan induced diabetic nephropathy. Indian J Pharm Pharmacol 2021;8(1):65-73

This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.