Indian Journal of Pharmacy and Pharmacology

Print ISSN: 2393-9079

Online ISSN: 2393-9087

CODEN : IJPPTK

Indian Journal of Pharmacy and Pharmacology (IJPP) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, research content, providing professional’s membership, and conducting conferences, seminars, and award programs. With more...

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Review Article


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10-16


Authors Details

Ingale Nikita S, Turankar Avinash V, Wagh Mitali S, Motghare Vijay M*


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Current status of Sodium-Glucose Co-Transporter Type 2 (SGLT2) inhibitors in treating diabetes mellitus


Review Article

Author Details : Ingale Nikita S, Turankar Avinash V, Wagh Mitali S, Motghare Vijay M*

Volume : 8, Issue : 1, Year : 2021

Article Page : 10-16

https://doi.org/10.18231/j.ijpp.2021.003



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Abstract

Background: Diabetes Mellitus is a spreading pandemic to the countries around the globe, despite of scientific breakthroughs and better healthcare facilities. Sodium-Glucose Co-Transporter Type 2 inhibitors (SGLT2i) are the latest class of oral anti-hyperglycemic agents that have been approved for the treatment of type II diabetes mellitus.
Aim: In this review, we have comprehended the evidence for antidiabetic and extra-glycaemic effects of SGLT2i.
Materials and Methods: The information is collected based on safety trials, randomized controlled trials (RCT), meta-analyses and real-world data.
Results: SGLT2i are rapidly establishing their role in the treatment of diabetes mellitus. The beneficial effects extend beyond glycaemic control, impressive cardio protective and Reno protective effects and included improvement in blood pressure, uric acid concentrations, body weight and oxidative stress.
Conclusion: Especially in patients with type 2 diabetes, SGLT2 inhibitors may be another option in those patients requiring additional glucose lowering and in those with acceptable risk factors. More research on the long term outcomes of SGLT2i is warranted.

Keywords: Canagliflozin, Dapagliflozin, Empagliflozin, Ertugliflozin, Sodium-glucose cotransporter-2 inhibitors, Sotagliflozin, Type 2 diabetes mellitus.


How to cite : Ingale Nikita S, Turankar Avinash V, Wagh Mitali S, Motghare Vijay M, Current status of Sodium-Glucose Co-Transporter Type 2 (SGLT2) inhibitors in treating diabetes mellitus. Indian J Pharm Pharmacol 2021;8(1):10-16

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