Indian Journal of Pharmacy and Pharmacology

Print ISSN: 2393-9079

Online ISSN: 2393-9087

CODEN : IJPPTK

Indian Journal of Pharmacy and Pharmacology (IJPP) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, research content, providing professional’s membership, and conducting conferences, seminars, and award programs. With more...

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73-76


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Devesh D Gosavi, Amit S Kamdi*, Suvarna M Kalambe, Pankaj N Bohra


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The motor coordination activity of alcoholic extract of Withania coagulans fruits in Swiss albino mice by rota rod test


Original Article

Author Details : Devesh D Gosavi, Amit S Kamdi*, Suvarna M Kalambe, Pankaj N Bohra

Volume : 7, Issue : 2, Year : 2020

Article Page : 73-76

https://doi.org/10.18231/j.ijpp.2020.015



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Abstract

Background: The central nervous system (CNS) depressant effect is caused by the numerous sedative and
hypnotic drugs that are currently used. Though in the late seventies some work was done on Withania
coagulans, it is the vulnerable species not widely scattered. Therefore, it was worthy to investigate the CNS
depressant activities of alcoholic extract of Withania coagulans fruits in Swiss albino mice by using rota
rod test.
Aim: To study the motor coordination activity of alcoholic extract of Withania coagulans fruits in Swiss
albino mice by Rota Rod Test.
Materials and Methods: Motor coordination was measured by using the Rota Rod Test. The CNS
depressant drugs reduce the endurance time of mice on the rotating rod as they weaken the motor
coordination so that mice fall early on the revolving rod. This endurance time is tested statistically among
the control, standard and the test drugs.
Statistical Analysis: One way ANOVA was used for the statistical analysis.
Results: The endurance time in Swiss albino mice was statistically highly significantly (p-value < 0> associated with the alcoholic extract of Withania coagulans fruits on rota rod test.
Conclusion: The alcoholic extract of Withania coagulans fruits established the CNS depressant activity in
Swiss albino mice by rota rod test.

Keywords: CNS depressant, Rota rod test, Swiss albino mice (SAM), Withania coagulans.


How to cite : Gosavi D D , Kamdi A S , Kalambe S M , Bohra P N, The motor coordination activity of alcoholic extract of Withania coagulans fruits in Swiss albino mice by rota rod test. Indian J Pharm Pharmacol 2020;7(2):73-76

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