Distribution of tumor-associated macrophages and M1/M2 polarization in different types and grades of ovarian tumors


Original Article

Author Details : Rusudan Devadze, Arsen Gvenetadze, George Burkadze, Shota Kepuladze*

Volume : 9, Issue : 4, Year : 2022

Article Page : 318-321

https://doi.org/10.18231/j.ijpo.2022.076



Suggest article by email

Get Permission

Abstract

Ovarian cancer represents one of the major causes of gynaecologic cancer mortality worldwide. Tumor-associated macrophages (TAM) are associated with the development and progression of ovarian cancer. TAMs are mainly represented by two types M1 and M2. We investigated the distribution of total, M1, M2 macrophages, tumor cell/macrophage ratio and M1/M2 ratio in mucinous and serous ovarian tumors. The study results showed that total TAM count is significantly higher in serous ovarian tumors, compared to mucinous tumors and the highest infiltration rate is detected in high-grade serous ovarian carcinomas. In addition, the number of M2 macrophages is significantly increased in higher-grade serous ovarian carcinomas. The evaluation of tumor/cell macrophage ratio could be used as an objective measure of macrophage infiltration in ovarian tumors.
 

Keywords: Tumor-associated macropages, Ovarian cancer, Tumor microenvironment.


How to cite : Devadze R, Gvenetadze A, Burkadze G, Kepuladze S, Distribution of tumor-associated macrophages and M1/M2 polarization in different types and grades of ovarian tumors. Indian J Pathol Oncol 2022;9(4):318-321


This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.







Article History

Received : 28-07-2022

Accepted : 20-08-2022


View Article

PDF File   Full Text Article


Copyright permission

Get article permission for commercial use

Downlaod

PDF File   XML File   ePub File


Digital Object Identifier (DOI)

Article DOI

https://doi.org/10.18231/j.ijpo.2022.076


Article Metrics






Article Access statistics

Viewed: 660

PDF Downloaded: 176



Medical Abbreviation List