Print ISSN:-2394-2789

Online ISSN:-2394-2797

CODEN : IJPCN9

Article History

Received : 11-02-2022

Accepted : 23-02-2022



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Quantitative estimation of molnupiravir by UV- Spectrophotometric method


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Original Article

Author Details : Pritam Jain*, Manali Bhamare, Sanjay Surana

Volume : 9, Issue : 1, Year : 2022

Article Page : 35-39

https://doi.org/10.18231/j.ijpca.2022.006



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Abstract

% A simple, rapid, accurate and economical UV-spectrophotometric method has been developed for estimation of Molnupiravir from bulk and pharmaceutical formulation. The ? of Molnupiravir in Distilled water was found to be 235 nm. The is for zero order of drug and for Zero order AUC. The AUC of the drug was found to be in the range of 228.00 – 243.40 nm. The drug follows linearity in the concentration range 5-30 µg/ml with correlation coefficient value 0.999. The proposed method was applied to pharmaceutical formulation and % amount of drug estimated 99.99was found in good agreement with the label claim. The accuracy of the method was checked by recovery experiment performed at three different levels i.e., 80%, 100% and 120 % w/w. The % recovery was found to be in the range 98.15%– 99.97% for method A and 98.85% — 99.56% for method B. The low values of % R.S.D. are indicative of the accuracy and reproducibility of the method. The precision of the method was studied as an intra-day, inter-day variations and repeatability. The % R.S.D. value less than 2 indicate that the method is precise. Ruggedness of the proposed method was studied with the help of two analysts. The above method was a rapid and cost-effective quality-control tool for routine analysis of Molnupiravir in bulk and in pharmaceutical dosage form.


Keywords: Molnupiravir, UV, Validation, quantitative determination



How to cite : Jain P, Bhamare M, Surana S, Quantitative estimation of molnupiravir by UV- Spectrophotometric method. Int J Pharm Chem Anal 2022;9(1):35-39


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