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Simultaneous analysis of eprosartan and hydrochlorothiazide in tablet formulation by High- Performance thin layer chromatography with ultraviolet absorption densitometry

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Original Article

Author Details : Vrushali Tambe*, Vijaya Vichare, Anupa Wagh, Surekha Wavhal

Volume : 8, Issue : 3, Year : 2021

Article Page : 123-128

https://doi.org/10.18231/j.ijpca.2021.024

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Abstract

A new, simple, accurate, and precise high-performance thin-layer chromatographic method has been established for simultaneous analysis of Eprosartan and Hydrochlorothiazide from a tablet formulation. Standard and sample solutions of Eprosartan and Hydrochlorothiazide were applied to precoated 250 ?m layer of silica gel G 60 F and the plates were developed with Chloroform: Acetonitrile: Glacial Acetic Acid (7:3:1,v/v/v) as mobile phase. Detection and evaluation of densitograms was performed densitometrically at 254 nm. The linear range was 200-700 ng/band with the retention factors of Eprosartan and Hydrochlorothiazide were 0.26± 0.02 and 0.44±0.02, respectively. The method was validated and successfully used for analysis of the drugs in tablets.

Keywords: Eprosartan, HPTLC, Hydrochlorothiazide, Tablets, Validation

How to cite : Tambe V, Vichare V, Wagh A, Wavhal S, Simultaneous analysis of eprosartan and hydrochlorothiazide in tablet formulation by High- Performance thin layer chromatography with ultraviolet absorption densitometry. Int J Pharm Chem Anal 2021;8(3):123-128

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