Effect of non-surgical periodontal therapy on salivary resistin and chemerin levels in type 2 diabetes mellitus with chronic periodontitis


Original Article

Author Details : Himanshu Aeran*, Amrinder Singh Tuli, Rebecca Chowdhry, Anissa Atif Mirza, Raman Kumar, Basant Kaur Aulakh

Volume : 8, Issue : 2, Year : 2022

Article Page : 128-134

https://doi.org/10.18231/j.ijohd.2022.026



Suggest article by email

Get Permission

Abstract

Background: A bidirectional relationship is seen between periodontal disease and diabetes mellitus. Adipokines like resistin and chemerin act as a proinflammatory molecule. Their action is mediated by the generation of pro-inflammatory cytokines and the stimulation of inflammatory cell chemotaxis to the site of inflammation.
Aim and Objectives: This study aimed to compare the levels of resistin and chemerin in saliva in diabetes mellitus type 2 and chronic periodontitis after non-surgical periodontal therapy (NSPT).
Materials and Methods: Forty-five subjects were recruited and divided into three groups – healthy controls (Group A), chronic periodontitis (Group B) and diabetes mellitus type 2 with chronic periodontitis (Group C). Group B and C received NSPT. The parameters included were gingival index, plaque index, clinical attachment loss and probing pocket depth which were evaluated at baseline and end of three months. Levels of resistin and chemerin in saliva were evaluated using resistin and chemerin enzyme linked immunosorbent assay (ELISA) kit.
Result: At 3 months, PI, GI, PPD and CAL was reduced statistically significant in B and C groups as compared PI and GI of group A. Salivary resistin and chemerin levels were also reduced significantly in all three groups except chemerin in group A. Mean salivary resistin and chemerin levels at baseline were highest in group C followed by group B and least in group A.
Conclusion: Non-surgical periodontal therapy reduces all clinical variables, resistin and chemerin levels. Salivary resistin and chemerin levels can be used as a likely biomarker to assess the outcome following NSPT.
 

Keywords: Combined oral contraception, Hormonal contraceptives, Progestin-only, Hypothalamic-pituitary-ovarian.


How to cite : Aeran H, Tuli A S, Chowdhry R, Mirza A A, Kumar R, Aulakh B K, Effect of non-surgical periodontal therapy on salivary resistin and chemerin levels in type 2 diabetes mellitus with chronic periodontitis. Int J Oral Health Dent 2022;8(2):128-134


This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.







Article History

Received : 22-05-2022

Accepted : 02-06-2022


View Article

PDF File   Full Text Article


Copyright permission

Get article permission for commercial use

Downlaod

PDF File   XML File   ePub File


Digital Object Identifier (DOI)

Article DOI

https://doi.org/10.18231/j.ijohd.2022.026


Article Metrics






Article Access statistics

Viewed: 744

PDF Downloaded: 235



Medical Abbreviation List