Indian Journal of Obstetrics and Gynecology Research

Print ISSN: 2394-2746

Online ISSN: 2394-2754

CODEN : IJOGCS

Indian Journal of Obstetrics and Gynecology Research (IJOGR) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, research content, providing professional’s membership, and conducting conferences, seminars, and award more...

Article type

Case Report


Article page

263-266


Authors Details

Monu Singh, B Preethi*, Achla Batra, Pallavi


Article Metrics


View Article As

 


Downlaod Files

   






Article statistics

Viewed: 854

PDF Downloaded: 682


Variant hook effect: A cause of false negative result in point of care testing


Case Report

Author Details : Monu Singh, B Preethi*, Achla Batra, Pallavi

Volume : 7, Issue : 2, Year : 2020

Article Page : 263-266

https://doi.org/10.18231/j.ijogr.2020.056



Suggest article by email

Get Permission

Abstract

Beta Human Chorionic Gonadotrophin (b hCG) assays are sandwich chromatographic immunoassays
which give a false negative results at high hCG concentrations and also in the presence of variants of
hCG like hyperglycosylated hCG and hCG core fragments. This is imperative in everyday clinical scenario
as it delays the diagnosis of pregnancy and its related complications. We have discussed two such cases
where in the first case the diagnosis of hydatidiform mole was delayed due hook effect whereas in the
second case the diagnosis of GTD was missed because of variant hook effect.

Keywords: Hcg – human chorionicganadotropin.


How to cite : Singh M, Preethi B , Batra A, Pallavi, Variant hook effect: A cause of false negative result in point of care testing. Indian J Obstet Gynecol Res 2020;7(2):263-266

This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.