Utility of CBNAAT, Cytology and Histology in diagnosis of suspected tubercular solid lymph node


Original Article

Author Details : Manju M D*, Madhusudhan A V

Volume : 5, Issue : 3, Year : 2020

Article Page : 168-172

https://doi.org/10.18231/j.ijirm.2020.052



Suggest article by email

Get Permission

Abstract

Background : Cytology, Ziehl Neelsen staining and Mantoux test are conventionally used to test and treat lymph node tuberculosis. Cartridge Based Nucleic Acid Amplification Test (CBNAAT) is being now recommended for diagnosis of all extrapulmonary tuberculosis including tubercular lymphadenitis. 
Aims and Objectives : To asses efficacy of various diagnostic tools for diagnosis of lymph node tuberculosis in solid state (non-caseating stage).
Material and Methods : It was a prospective study conducted by including all consecutive patients with lymph node swelling suggestive of tuberculosis. Fine needle aspirate was subjected for cytology and CBNAAT. If both turned negative, excision biopsy was performed and subjected for histology. Results were tabulated.
Results : Sixty patients were included after excluding certain patients with caseous aspiration. Thirtyone (51.67%) had mycobacterium detected in CBNAAT. Remaining patients after histology had following diagnosis; Tuberculosis in eight, nonspecific reactive hyperplasia in 11, metastasis and lymphoma in four and Non Tubercular Mycobacteria and actinomycosis in one each patient.
Conclusion : CBNAAT is an effective tool for diagnosing lymph node tuberculosis even in early stages of pathology. Relying solely on cytology to diagnose tuberculosis should be discouraged.

Keywords: Caseation, CBNAAT, Cytology, Excision biopsy, Lymphadenopathy, Tuberculosis.


How to cite : Manju M D, Madhusudhan A V, Utility of CBNAAT, Cytology and Histology in diagnosis of suspected tubercular solid lymph node. IP Indian J Immunol Respir Med 2020;5(3):168-172


This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.







View Article

PDF File   Full Text Article


Copyright permission

Get article permission for commercial use

Downlaod

PDF File   XML File   ePub File


Digital Object Identifier (DOI)

Article DOI

https://doi.org/10.18231/j.ijirm.2020.052


Article Metrics






Article Access statistics

Viewed: 3108

PDF Downloaded: 790



Medical Abbreviation List