Indian Journal of Clinical and Experimental Ophthalmology

Print ISSN: 2395-1443

Online ISSN: 2395-1451

CODEN : IJCEKF

Indian Journal of Clinical and Experimental Ophthalmology (IJCEO) is open access, a peer-reviewed medical journal, published quarterly, online, and in print, by the Innovative Education and Scientific Research Foundation (IESRF) since 2015. To fulfil our aim of rapid dissemination of knowledge, we publish articles ‘Ahead of Print’ on acceptance. In addition, the journal allows free access (Open Access) to its content, which is likely to attract more readers and citations of articles published in IJCEO. Manuscripts must be prepared in more...

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Original Article


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520-524


Authors Details

Manoj S , Sameer Iqbal*, Narendra Meel, Unnikrishnan Nair


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To compare the short-term efficacy and safety of combination therapy with standard fluence and reduced fluence PDT in polypoidal choroidal vasculopathy


Original Article

Author Details : Manoj S , Sameer Iqbal*, Narendra Meel, Unnikrishnan Nair

Volume : 8, Issue : 4, Year : 2022

Article Page : 520-524

https://doi.org/10.18231/j.ijceo.2022.105



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Abstract

Purpose:   To evaluate and compare the efficacy of reduced-fluence photodynamic therapy (PDT) with standard-fluence photodynamic therapy in treating polypoidal choroidal vasculopathy.
Materials and Methods:   Twenty-eight eyes (27 patients) with polypoidal choroidal vasculopathy were retrospectively analysed; 14 eyes received Indocyanine green angiography-guided standard-fluence (SF) PDT (50 J/cm) and 14 eyes received Indocyanine green angiography-guided reduced-fluence (RF) PDT (25 J/cm). Primary outcome measured after 6 months of treatment were the changes in mean BCVA, polyp regression, polyp PED height, central choroidal thickness (CCT), post PDT intravitreal anti VEGF injection need and complications.
Results: Results of both the groups were comparable at 6 months follow up. Mean change in log mar visual acuity at 6 months for the SF PDT group was 0.12 compared to 0.13 for the RF PDT group (p?=?0.919).  Mean change in PED height at 6 months for the SF PDT group was 159 ?m compared to 172 ?m for the RF PDT group (p?=?0.06). Mean change in CCT at 6 months for the SF PDT group was 45?m compared to 10?m for the RF PDT group (p?=?0.96). While the SF PDT group needed a mean of 2 injections post PDT, the RF PDT group required a mean of 3 injections during the course of 6 months follow up. Neither of the group reported any adverse effects following the procedure.
Conclusions:  Our study demonstrated that reduced-fluence PDT is at least on par with standard-fluence PDT in management of PCV.
 

Keywords: Polypoidal choroidal vasculopathy, Photodynamic therapy, Reduced fluence PDT, Standard fluence PDT.


How to cite : Manoj S, Iqbal S, Meel N, Nair U, To compare the short-term efficacy and safety of combination therapy with standard fluence and reduced fluence PDT in polypoidal choroidal vasculopathy. Indian J Clin Exp Ophthalmol 2022;8(4):520-524

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