Indian Journal of Clinical and Experimental Ophthalmology

Print ISSN: 2395-1443

Online ISSN: 2395-1451

CODEN : IJCEKF

Indian Journal of Clinical and Experimental Ophthalmology (IJCEO) is open access, a peer-reviewed medical journal, published quarterly, online, and in print, by the Innovative Education and Scientific Research Foundation (IESRF) since 2015. To fulfil our aim of rapid dissemination of knowledge, we publish articles ‘Ahead of Print’ on acceptance. In addition, the journal allows free access (Open Access) to its content, which is likely to attract more readers and citations of articles published in IJCEO. Manuscripts must be prepared in more...

Article type

Case Series


Article page

290-294


Authors Details

Avijit Saha*, Somnath Chowdhury


Article Metrics


View Article As

 


Downlaod Files

   






Article statistics

Viewed: 256

PDF Downloaded: 204


Case series of Euthyroid Graves’ Ophthalmopathy in patients seronegative for TSH receptor autoantibody (TRAb) & developed Hyperthyroidism in follow-up visits


Case Series

Author Details : Avijit Saha*, Somnath Chowdhury

Volume : 8, Issue : 2, Year : 2022

Article Page : 290-294

https://doi.org/10.18231/j.ijceo.2022.058



Suggest article by email

Get Permission

Abstract

We reported cases of Graves’ ophthalmopathy who presented solely with symptoms of the eyes and normal thyroid function tests, negative TSH receptor autoantibody (TRAb). These cases were referred to our hospital for unilateral or bilateral eye swelling with painful eye movements, with or without double vision, without any signs or symptoms of hyper- or hypothyroidism. Serum thyroid function tests and 99mTc uptake studies were within the normal range. Anti-thyroid autoantibodies (TRAb) were negative in all the cases. Since orbital CT scan and MRI gave typical results compatible with Graves’ ophthalmopathy and after exclusion of other possibilities, these patients were treated with corticosteroid pulse therapy and orbital radiation therapy, leading to a partial improvement of the symptoms. We followed up those cases with serial thyroid profile testing and TRAb estimation and they were subsequently developed clinical & biochemical hyperthyroidism within the next 18 months follow-up. At that time, they also became TRAb positive. These cases give us insight into the potential pathophysiologic mechanism underlying Graves’ ophthalmopathy and cast light upon the difficulties of establishing the diagnosis in biochemically euthyroid & thyroid autoantibody negative cases. Clinicians should be aware of the variable temporal relationship between the clinical expression of thyroid dysfunction and orbital disease in the natural course of Graves’ disease.
 

Keywords: Graves’ ophthalmopathy, Thyroid receptor Antibody(TRAb).


How to cite : Saha A, Chowdhury S, Case series of Euthyroid Graves’ Ophthalmopathy in patients seronegative for TSH receptor autoantibody (TRAb) & developed Hyperthyroidism in follow-up visits. Indian J Clin Exp Ophthalmol 2022;8(2):290-294

This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.