Indian Journal of Clinical and Experimental Ophthalmology

Print ISSN: 2395-1443

Online ISSN: 2395-1451

CODEN : IJCEKF

Indian Journal of Clinical and Experimental Ophthalmology (IJCEO) is open access, a peer-reviewed medical journal, published quarterly, online, and in print, by the Innovative Education and Scientific Research Foundation (IESRF) since 2015. To fulfil our aim of rapid dissemination of knowledge, we publish articles ‘Ahead of Print’ on acceptance. In addition, the journal allows free access (Open Access) to its content, which is likely to attract more readers and citations of articles published in IJCEO. Manuscripts must be prepared in more...

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Original Article


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376-380


Authors Details

Neepa Gohil, Kaumudi K Shinde*, Yash Solanki


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Assessment of efficacy and safety of intravitreal ranibizumab in patients with macular edema secondary to retinal vein occlusion


Original Article

Author Details : Neepa Gohil, Kaumudi K Shinde*, Yash Solanki

Volume : 7, Issue : 2, Year : 2021

Article Page : 376-380

https://doi.org/10.18231/j.ijceo.2021.074



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Abstract

Background: The aim of the study was to assess the efficacy and safety of individualized repeated injection of intravitreal anti-VEGF ranibizumab for preserving or improving vision (BCVA) and central foveal thickness (CFT) in macular edema secondary to retinal vein occlusion (RVO).
Materials and Methods: 25 eyes of 25 patients with RVO were included. General and systemic examination was done. IOP measurement, slit lamp, fundus examination, BCVA assessment and OCT was done. CFT was measured to assess macular edema. Injection intravitreal ranibizumab (0.5mg/0.05ml) was given in the affected eye, every 6 weeks, till week 18, if CFT>250 µm. Total 3 injections were given in each patient. Final follow-up visit was at week 36.
Results: Hypertension (72%), DM (20%) and altered lipid profile (16%) were associated comorbidities. There was significant reduction in mean CFT from baseline visit (516.08±35.21) to week 18 visit (203.32±4.97) with P<0 P=0.44).> There was significant improvement in mean BCVA from baseline visit (0.87±0.03) to week 18 visit (0.27±0.03). There was no significant statistical difference between week 18 BCVA and week 36 BCVA (P=0.76). There was a significant reduction in mean BCVA from baseline visit (0.87±0.03) to week 36(0.35±0.05) with P<0> Conclustion: Individualized repeated intravitreal injection of ranibizumab showed improvement in BCVA and CFT in patients with macular edema secondary to RVO. For long term maintenance, control of systemic comorbidities is essential.


Keywords: Intravitreal ranibizumab, Macular edema, Retinal vein occlusion.


How to cite : Gohil N, Shinde K K, Solanki Y, Assessment of efficacy and safety of intravitreal ranibizumab in patients with macular edema secondary to retinal vein occlusion. Indian J Clin Exp Ophthalmol 2021;7(2):376-380

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