Indian Journal of Clinical and Experimental Ophthalmology

Print ISSN: 2395-1443

Online ISSN: 2395-1451

CODEN : IJCEKF

Indian Journal of Clinical and Experimental Ophthalmology (IJCEO) is open access, a peer-reviewed medical journal, published quarterly, online, and in print, by the Innovative Education and Scientific Research Foundation (IESRF) since 2015. To fulfil our aim of rapid dissemination of knowledge, we publish articles ‘Ahead of Print’ on acceptance. In addition, the journal allows free access (Open Access) to its content, which is likely to attract more readers and citations of articles published in IJCEO. Manuscripts must be prepared in more...

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Short Communication


Article page

660-663


Authors Details

Nischala Balakrishna*, Alhaj F Tasneem, Vittal I Nayak, Nagalakshmi Narayanaswamy, Sara Nastain


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A rare case of oguchi disease exhibiting the classic Mizuo-Nakamura phenomenon


Short Communication

Author Details : Nischala Balakrishna*, Alhaj F Tasneem, Vittal I Nayak, Nagalakshmi Narayanaswamy, Sara Nastain

Volume : 6, Issue : 4, Year : 2020

Article Page : 660-663

https://doi.org/10.18231/j.ijceo.2020.141



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Abstract

Introduction: Oguchi disease also called congenital stationary night blindness is an autosomal recessivegenetic condition first identified in Japan with a few cases reported in other countries like Europe, America, India and Pakistan. We report one such case exhibiting the Mizuo-Nakamura phenomenon with a reduced amplitude on the b-wave of the rod electroretinogram advocating this diagnosis.
Case Report: A 40-year-old man presented with complaints of non-progressive decrease in vision as the day progressed for 6 months with normal vision during the day in both eyes. There was no history of trauma or any other ocular or systemic disease. His parents had a second-degree consanguineous marriage and his father experienced similar symptoms. Visual acuity for distance was 6/6 and N6 for near in both eyes. His anterior segment and posterior segments were normal. When the patient was put to dark adaptation for 3 hours, there was a change in his fundus background colour from grey to red (Mizuo-Nakamura phenomenon). The b-wave amplitude was decreased on the rod electroretinogram. The cone electroretinogram on the other hand was normal. All this was confirmed by his genetic study which favoured this diagnosis.
Conclusion: This disease presents with features similar to retinitis pigmentosa in terms of mutations in the SAG gene. This highlights the importance of the Mizou-Nakamura phenomenon in formulating a confirmatory diagnosis and treatment protocol.

Keywords: Congenital stationary night blindness, Mizuo-Nakamura phenomenon, Oguchi disease, Rod electroretinogram.


How to cite : Balakrishna N , Tasneem A F , Nayak V I , Narayanaswamy N , Nastain S , A rare case of oguchi disease exhibiting the classic Mizuo-Nakamura phenomenon. Indian J Clin Exp Ophthalmol 2020;6(4):660-663

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