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Role of thrombophilia testing in retinal vein occlusion: single centre experience from Oman

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Original Article

Author Details : Khalid N Al Hashmi*, Fahad Al-Ghafri, Anil Pathare

Volume : 6, Issue : 4, Year : 2020

Article Page : 497-500

https://doi.org/10.18231/j.ijceo.2020.107

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Abstract

Background: Thrombophilia is a known predisposition to venous thromboembolism however there was no significant relationship with retinal vein occlusion (RVO). Herein, we aimed to study the prevalence of thrombophilia among Omani patients presented with RVO.
Material and Methods: In a retrospective study, 11 consecutive patients diagnosed by the ophthalmologists at Armed Forces Hospital with RVO (central RVO, n=7; branch RVO, n=4) were included. Thrombophilia testing including factor V Leiden, Prothrombin gene mutation (G20210A) and Janus Kinase-2 (JAK2 V617F) mutation analysis; presence of autoantibodies including Antinuclear antibody(ANA), Anti-neutrophil cytoplasmic antibody (ANCA), Lupus anticoagulant (LA), Anticardiolipin
antibody (ACA), Anti-B2 glycoprotein positivity; abnormal coagulation protein levels including protein S, Protein C, Anti-thrombin and Factor VIII as well as biochemical parameters like elevated serum lipoprotein 1a, triglycerides, total cholesterol and homocysteine levels were performed.
Results: Patient’s ages ranged between 25 to 75 years (mean + SD; 48.8 + 13.6) with a mild male preponderance (54.5%). None of them gave history of smoking. However, 27.3% and 45.5% had history of diabetes and hypertension, respectively. Amongst the thrombophilia tests evaluated, only one patient was positive for an underlying Prothrombin gene (G20210A) heterozygosity, another patient was positive for Anti-beta2 glycoprotein antibody and one patient with high serum homocystine.
Conclusion: Our study demonstrated that thrombophilia is not prevalent in omani patients diagnosed with RVO in the armed forces hospital. Furthermore, 27.3% and 45.5% of those patients were suffering from diabetes and hypertension, respectively which are known risk factors for RVO.

Keywords: BRVO, CRVO, Retinal vein occlusion, RVO, Thrombophilia.

How to cite : Hashmi K N A, Al-ghafri F , Pathare A , Role of thrombophilia testing in retinal vein occlusion: single centre experience from Oman. Indian J Clin Exp Ophthalmol 2020;6(4):497-500

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