Indian Journal of Clinical and Experimental Ophthalmology

Print ISSN: 2395-1443

Online ISSN: 2395-1451

CODEN : IJCEKF

Indian Journal of Clinical and Experimental Ophthalmology (IJCEO) is open access, a peer-reviewed medical journal, published quarterly, online, and in print, by the Innovative Education and Scientific Research Foundation (IESRF) since 2015. To fulfil our aim of rapid dissemination of knowledge, we publish articles ‘Ahead of Print’ on acceptance. In addition, the journal allows free access (Open Access) to its content, which is likely to attract more readers and citations of articles published in IJCEO. Manuscripts must be prepared in more...

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Original Article


Article page

497-500


Authors Details

Khalid N Al Hashmi*, Fahad Al-Ghafri, Anil Pathare


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Role of thrombophilia testing in retinal vein occlusion: single centre experience from Oman


Original Article

Author Details : Khalid N Al Hashmi*, Fahad Al-Ghafri, Anil Pathare

Volume : 6, Issue : 4, Year : 2020

Article Page : 497-500

https://doi.org/10.18231/j.ijceo.2020.107



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Abstract

Background: Thrombophilia is a known predisposition to venous thromboembolism however there was no significant relationship with retinal vein occlusion (RVO). Herein, we aimed to study the prevalence of thrombophilia among Omani patients presented with RVO.
Material and Methods: In a retrospective study, 11 consecutive patients diagnosed by the ophthalmologists at Armed Forces Hospital with RVO (central RVO, n=7; branch RVO, n=4) were included. Thrombophilia testing including factor V Leiden, Prothrombin gene mutation (G20210A) and Janus Kinase-2 (JAK2 V617F) mutation analysis; presence of autoantibodies including Antinuclear antibody(ANA), Anti-neutrophil cytoplasmic antibody (ANCA), Lupus anticoagulant (LA), Anticardiolipin
antibody (ACA), Anti-B2 glycoprotein positivity; abnormal coagulation protein levels including protein S, Protein C, Anti-thrombin and Factor VIII as well as biochemical parameters like elevated serum lipoprotein 1a, triglycerides, total cholesterol and homocysteine levels were performed.
Results: Patient’s ages ranged between 25 to 75 years (mean + SD; 48.8 + 13.6) with a mild male preponderance (54.5%). None of them gave history of smoking. However, 27.3% and 45.5% had history of diabetes and hypertension, respectively. Amongst the thrombophilia tests evaluated, only one patient was positive for an underlying Prothrombin gene (G20210A) heterozygosity, another patient was positive for Anti-beta2 glycoprotein antibody and one patient with high serum homocystine.
Conclusion: Our study demonstrated that thrombophilia is not prevalent in omani patients diagnosed with RVO in the armed forces hospital. Furthermore, 27.3% and 45.5% of those patients were suffering from diabetes and hypertension, respectively which are known risk factors for RVO.

Keywords: BRVO, CRVO, Retinal vein occlusion, RVO, Thrombophilia.


How to cite : Hashmi K N A, Al-ghafri F , Pathare A , Role of thrombophilia testing in retinal vein occlusion: single centre experience from Oman. Indian J Clin Exp Ophthalmol 2020;6(4):497-500

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