A study of antifungal susceptibility pattern of dermatophytes at tertiary care center


Original Article

Author Details : Krishnendra Varma, Ujjwal Kumar, Yogyata Marothi, Mahendra Pratap Singh Chouhan, Siddharth Sethi*

Volume : 7, Issue : 3, Year : 2021

Article Page : 232-236

https://doi.org/10.18231/j.ijced.2021.044



Suggest article by email

Get Permission

Abstract

Introduction: Dermatophytes are fungi that can cause infections of the skin, hair & nails due to their ability to invade keratin. Dermatophytosis is the most common superficial fungal infection worldwide; it is common in tropics and subtropical regions. It may present in epidemic proportions in areas of high humidity.
Objective: The present study aimed to identify various species causing dermatophytosis & to determine the invitro susceptibility pattern against commonly used systemic antifungal agents in our tertiary care center. 
Material and Methods: A total of 149 samples were collected of infected skin, hair and nails in a period of 1 year from January 2020 to December 2020. Samples were collected under aseptic condition by skin scrapping, nail and hair clipping by using scalpel or forceps. Identification of the causative pathogen was done by performing slide culture, lacto-phenol cotton blue mount, hair perforation tests and urease tests. We adopted a newly developed agar based disk diffusion assay to test susceptibility of clinically isolated dermatophytes for antifungal susceptibility testing.
Results: Microbiological investigations revealed the presence of dermatophytic fungi in 71.8% of the samples. Trichophyton rubrum was the predominant pathogen isolated. The study showed Itraconazole to be most effective antifungal drugs against dermatophytes followed by terbinafine and fluconazole. 
Conclusions: Further intensive epidemiological and invitro antifungal susceptibility studies of dermatophytes are required which will have more public health significance.
 

Keywords: Dermatophytes, Antifungals, Susceptibility


How to cite : Varma K , Kumar U, Marothi Y , Chouhan M P S, Sethi S , A study of antifungal susceptibility pattern of dermatophytes at tertiary care center. IP Indian J Clin Exp Dermatol 2021;7(3):232-236


This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.







Article History

Received : 23-01-2021

Accepted : 23-07-2021


View Article

PDF File   Full Text Article


Copyright permission

Get article permission for commercial use

Downlaod

PDF File   XML File   ePub File


Digital Object Identifier (DOI)

Article DOI

https://doi.org/10.18231/j.ijced.2021.044


Article Metrics






Article Access statistics

Viewed: 895

PDF Downloaded: 375



Medical Abbreviation List