International Journal of Clinical Biochemistry and Research

Print ISSN: 2394-6369

Online ISSN: 2394-6377

CODEN : IJCBK6

International Journal of Clinical Biochemistry and Research (IJCBR) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, research content, providing professional’s membership, and conducting conferences, seminars, and award more...

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Original Article


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123-126


Authors Details

Ravinder Kaur*, Harjitpal Singh, Rajinder Singh Yadav


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Prevalence of vitamin B deficiency in patients with thyroid disorders: A study from Himalayan region


Original Article

Author Details : Ravinder Kaur*, Harjitpal Singh, Rajinder Singh Yadav

Volume : 9, Issue : 2, Year : 2022

Article Page : 123-126

https://doi.org/10.18231/j.ijcbr.2022.025



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Abstract

Background: Endocrine disorders are on the rise world over. Diseases of thyroid gland are among the most prevalent endocrine disorders in the world, second only to diabetes mellitus. In India, autoimmune thyroid disorders have been estimated to be the most frequent endocrine disorders. Thyroid diseases are more prevalent in the sub Himalayan region even in post iodination phase.
Aim: To assess the prevalence of auto immune thyroid disease and vitamin B12 deficiency in patients with thyroid disorders in Himalayan region.
Materials and Methods: Study population comprised of patients above 18 years of age, who were advised thyroid function tests by the clinicians on an outpatient basis. Patients who were critically ill were excluded from the study. Thyroid function tests (T3, T4, TSH) along with anti thyroperoxidase antibody (ATA) was done by chemiluminescence and vitamin B12 levels were done by chemiluminiscent enzyme immunoassay after serum separation of 120 subjects. ATA level >50uIU/ml was taken as positive and Vitamin B12 deficiency was taken as a value less than 160 pg/ml.
Results: Mean age of study population was 42.48 (± 12.32) years. Forty hypothyroid and forty hyperthyroid and 40 controls were recruited. ATA positivity was reported in 52.5% (63/120) of the samples. In the present study more than 50% of cases with thyroid disorder and ATA positivity showed deficiency of vitamin B12 (hypothyroidism 63.3% hyperthyroidism, 51.8%).
Conclusion: All patients with thyroid dysfunction should be screened for vitamin B12 status and treated accordingly.
 

Keywords: Vitamin B12 deficiency, Thyroid disorder, Anti thyroperoxidase antibody.


How to cite : Kaur R, Singh H, Yadav R S, Prevalence of vitamin B deficiency in patients with thyroid disorders: A study from Himalayan region. Int J Clin Biochem Res 2022;9(2):123-126

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