International Journal of Clinical Biochemistry and Research

Print ISSN: 2394-6369

Online ISSN: 2394-6377

CODEN : IJCBK6

International Journal of Clinical Biochemistry and Research (IJCBR) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, research content, providing professional’s membership, and conducting conferences, seminars, and award more...

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Original Article


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384-387


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Noopur Gajjar*, Vandana Peddiwar, Mitul Prajapati


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Role of serum immunoglobulins in patients of oral lichen planus and oral lichenoid reaction


Original Article

Author Details : Noopur Gajjar*, Vandana Peddiwar, Mitul Prajapati

Volume : 7, Issue : 3, Year : 2020

Article Page : 384-387

https://doi.org/10.18231/j.ijcbr.2020.082



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Abstract

Introduction: The aim of the study is to find out the role of immunoglobulin IgA and IgM as indicators
of humoral immune response in the etiopathogenesis and for the differentiation between oral lichen planus
(OLP) and oral lichenoid reaction (OLR).
Materials and Methods: The study comprises of 50 patients. From them 20 patients were of OLP, 20
patients of OLR and 10 patients as controls. After histopathological confirmation, approximately 5 ml of
venous blood was collected by venepuncture from OLP patients, OLR patients and from control patients.
The serum IgA and IgM were measured by immunoturbidimetry method using automated chemistry
analyzer and data were analysed using t-test.
Results: The mean serum level of IgA and IgM was 2.14±1.19g/L and 0.88±0.47g/L respectively
in reticular OLP, 2.21±0.98g/L and 0.78±0.49g/L respectively in erosive OLP, 1.64±0.60g/L and
0.99±0.34g/L respectively in OLR, 2.62±0.40g/L and 1.51±0.47g/L respectively in control patients. The
results showed statistically significant IgM level for reticular and Erosive OLP (p value=0.007 and 0.042
respectively).
Conclusion: Patients with OLP shows systemic immunologic alterations suggest that humoral immune
system may play a part in pathogenesis of OLP and also OLP and OLR lesions can be differentiate on the
basis of serum level of IgM.

Keywords: Humoral immunity, IgA, IgM, Oral lichen planus, Oral lichenoid reactions.


How to cite : Gajjar N , Peddiwar V , Prajapati M , Role of serum immunoglobulins in patients of oral lichen planus and oral lichenoid reaction. Int J Clin Biochem Res 2020;7(3):384-387

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