International Journal of Clinical Biochemistry and Research

Print ISSN: 2394-6369

Online ISSN: 2394-6377

CODEN : IJCBK6

International Journal of Clinical Biochemistry and Research (IJCBR) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, research content, providing professional’s membership, and conducting conferences, seminars, and award more...

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Original Article


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343-348


Authors Details

Prema Adhikari, Suryakant Nagtilak*, Pawan Parashar


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Relationship between adiponectin & uric acid with inflammation in pathogenesis of metabolic syndrome


Original Article

Author Details : Prema Adhikari, Suryakant Nagtilak*, Pawan Parashar

Volume : 7, Issue : 3, Year : 2020

Article Page : 343-348

https://doi.org/10.18231/j.ijcbr.2020.074



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Abstract

Background: The risk factors of Metabolic syndrome (Mets), primarily favors the development of
cardiometabolic alteration, type 2 diabetes, hypertension, and dyslipidemia leading to increase in morbidity.
Life style and eating habits often increases the levels of Uric acid (UA) in circulation. Elevated UA &
stress, exacerbates the pain and inflammation. The inflammatory response includes systemic increase in
circulating inflammatory cytokines and acute phase protein, high sensitive C-reactive protein (hs-CRP).
Adiponectin (ADI) a cytokines primarily secreted by adipocytes exerts antidiabetic, anti-inflammatory &
cardioprotective effects. Thus the purpose of the study is to establish a link between Adiponectin, Uric acid
and hs-CRP which may further be used in diagnosis and thus can positively reverse many of the adverse
effects of MetS.
Material and Methods: Present study, an observational case-control study conducted on referred MetS
patients attending OPD at Chhatrapati Shivaji Subharti Hospital, Meerut. Data collected on previously
validated questionnaire from 235 subjects (156 with MetS and 79 non-MetS) assessed for anthropometric
measurements, diabetic profile, ADI, UA & hs-CRP were evaluated by standard established techniques.
Results: The results obtained from Mets patients were compared with non-MetS subjects, where ADI was
significantly lower (P<0> In Spearman’s rank correlation coefficient for the relationship between ADI and metabolic variables -
ADI was positively correlated with age, diastolic blood pressure, total cholesterol, HDL-C& LDL-C
while negatively correlated with BMI, systolic blood pressure, fasting glucose, Triglyceride& VLDL-C.
Serum hs-CRP levels were elevated with the increasing number of MetS components, being higher among
those with > 2 components of MetS while adiponectin decreasing with the number of MetS components.
Decreased levels were reported for ADI, whereas hs-CRP & UA levels were escalating.
Conclusion: Higher levels of hs-CRP & Uric Acid with lower level of ADI associated with significantly
higher risk of MetS.

Keywords: Obesity, Adiponectin, Uric acid, hs-CRP, Metabolic syndrome.


How to cite : Adhikari P , Nagtilak S , Parashar P , Relationship between adiponectin & uric acid with inflammation in pathogenesis of metabolic syndrome. Int J Clin Biochem Res 2020;7(3):343-348

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