International Journal of Clinical Biochemistry and Research

Print ISSN: 2394-6369

Online ISSN: 2394-6377

CODEN : IJCBK6

International Journal of Clinical Biochemistry and Research (IJCBR) open access, peer-reviewed quarterly journal publishing since 2014 and is published under auspices of the Innovative Education and Scientific Research Foundation (IESRF), aim to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. IESRF is dedicated to the transfer of technology and research by publishing scientific journals, research content, providing professional’s membership, and conducting conferences, seminars, and award more...

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Original Article


Article page

232-237


Authors Details

Balasaheb H Jadhav, Madhav G Kalekar*, Syed Abdul Jaweed, Poornima Shelke


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Comparative evaluation of enzymatic and non-enzymatic antioxidants in alzheimer dementia


Original Article

Author Details : Balasaheb H Jadhav, Madhav G Kalekar*, Syed Abdul Jaweed, Poornima Shelke

Volume : 7, Issue : 2, Year : 2020

Article Page : 232-237

https://doi.org/10.18231/j.ijcbr.2020.050



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Abstract

The senile dementia is a neurodegenerative disease characterized by loss of memory, attention and
cognitive functions. The oxidants- antioxidant plays important role by several mechanism by reducing toxic
Amyloid-b in neurons The Alzheimer’s disease is due to Amyloid-b deposition in the brain and production
of neurofibrillary tangles. Amyloid-b induces reactive oxygen species in brain of Alzheimer dementia
patients. In the present study we evaluated the levels of Superoxide dismutase, Glutathione peroxidase,
Catalase, Vitamin C and Vitamin E and Vitamin B6 in Alzheimer dementia patients. It has been observed
lower levels of Enzymatic, Non-Enzymatic Antioxidants and increased serum levels of malondialdehyde
significantly in Alzheimer’s dementia patients as compared to healthy controls (p < 0> oxidative stress markers may play important role in neurodegenerative diseases like Senile dementia. Serum
levels of Superoxide dismutase, Glutathione peroxidase, Catalase, Vitamin C and Vitamin E and Vitamin
B6 and Malondialdehyde (indicator of Lipid peroxidation) were measured using standard methods in 50
healthy controls and 50 Alzheimer’s dementia patients.

Keywords: Superoxide dismutase (SOD), Glutathione peroxidase (GSH-Px), MDA (Malondialdehyde), Ascorbic acid (Vit C), Alpha-Tocopherol (Vit E), Amyloid-b (Ab), Reactive oxygen species (ROS).


How to cite : Jadhav B H, Kalekar M G, Jaweed S A, Shelke P , Comparative evaluation of enzymatic and non-enzymatic antioxidants in alzheimer dementia. Int J Clin Biochem Res 2020;7(2):232-237

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