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Future outlook hydrodynamic drug delivery system of solid oral dosage form: Review

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Review Article

Author Details : Akhilesh Kumar Singh*, Neeraj Sharma

Volume : 6, Issue : 3, Year : 2021

Article Page : 96-101

https://doi.org/10.18231/j.ijcaap.2021.018

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Abstract

Over the last few years, therapeutic efficacy of drugs that have poor bioavailability or narrow absorption window have challenged the pharmaceutical industry. In this framework, many Hydrodynamic Balance System (HBS) also known as Gastro retentive dosage forms (GRDFs) have been used to enhance the therapeutic efficacy of drugs. Such drug have a narrow absorption window, are unstable at higher pH, are soluble in acidic conditions, and are local effect in the gastric-part. The drug development with recent technology of various novel polymeric-based gastroretentive drug delivery technologies that may regulate the bioavailability and extend time of therapeutic efficacy of such drugs. Our focus on the significance of in vitro study and in vivo evaluation parameters of various HBS drugs along with their applications.  This study provides a promising platform for advantages and guide formulation of HBS dosage form were covered in detail.
 

Keywords: Hydrodynamic Balance Drug Delivery System, Gastric Retention Time, narrow absorption window, Floating formulation

How to cite : Singh A K, Sharma N, Future outlook hydrodynamic drug delivery system of solid oral dosage form: Review. IP Int J Compr Adv Pharmacol 2021;6(3):96-101

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