Print ISSN:-2394-4781

Online ISSN:-2394-4994

CODEN : IJCACT

Article History

Received : 17-12-2020

Accepted : 05-01-2021



Article Metrics




Downlaod Files

   


Article Access statistics

Viewed: 595

PDF Downloaded: 382


A randomised controlled double blind study to assess the effect of oral tizanidine premedication on intraoperative isoflurane consumption in patients undergoing laparoscopic surgeries under general anaesthesia


Full Text PDF Share on Facebook Share on Twitter


Original Article

Author Details : Bhargavi Sanket, Samudyatha T J*, Nethra S Surhonne, Sudheesh Kannan, Swathi Nagaraj

Volume : 8, Issue : 2, Year : 2021

Article Page : 214-220

https://doi.org/10.18231/j.ijca.2021.043



Suggest article by email

Get Permission

Abstract

Background: Tizanidine is an  2 receptor agonist derived from clonidine with primary central myotonolytic action along with antinociceptive and anticonvulsant action. Unlike clonidine, there are few studies evaluating the role of tizanidine as an effective anaesthetic premedication. Hence this study was undertaken to evaluate oral tizanidine [2 mg and 4 mg] administered preoperatively in decreasing the intraoperative consumption of isoflurane.
Materials and Methods: This prospective, randomised, double blind control trial was undertaken in 75 adult patients scheduled for elective laparoscopic surgeries. The subjects were randomly allocated into 3 groups with Group A (2 mg tizanidine), Group B (4 mg tizanidine), Group C (sugar pellet). The study drug was administered orally 90 minutes preoperatively. Intraoperative isoflurane consumption and end tidal isoflurane was recorded.
Results: Demographic data was comparable between the 3 groups. We observed a significant fall in isoflurane consumption in the tizanidine groups [Total: group A = 10.24 (2.07) ml, group B = 8.09 (2.17) ml, group C = 15.43 (4.77), p < 0 xss=removed xss=removed xss=removed xss=removed xss=removed xss=removed xss=removed xss=removed xss=removed> Conclusions: Oral tizanidine [2mg and 4 mg] is as effective and safe anaesthetic premedication in decreasing isoflurane consumption.

Keywords: Alpha 2 agonist, Isoflurane, Laparoscopic, Premedication, Tizanidine.



How to cite : Sanket B , Samudyatha T J, Surhonne N S , Kannan S , Nagaraj S , A randomised controlled double blind study to assess the effect of oral tizanidine premedication on intraoperative isoflurane consumption in patients undergoing laparoscopic surgeries under general anaesthesia. Indian J Clin Anaesth 2021;8(2):214-220


This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.