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A randomised controlled double blind study to assess the effect of oral tizanidine premedication on intraoperative isoflurane consumption in patients undergoing laparoscopic surgeries under general anaesthesia

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Original Article

Author Details : Bhargavi Sanket, Samudyatha T J*, Nethra S Surhonne, Sudheesh Kannan, Swathi Nagaraj

Volume : 8, Issue : 2, Year : 2021

Article Page : 214-220

https://doi.org/10.18231/j.ijca.2021.043

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Abstract

Background: Tizanidine is an  2 receptor agonist derived from clonidine with primary central myotonolytic action along with antinociceptive and anticonvulsant action. Unlike clonidine, there are few studies evaluating the role of tizanidine as an effective anaesthetic premedication. Hence this study was undertaken to evaluate oral tizanidine [2 mg and 4 mg] administered preoperatively in decreasing the intraoperative consumption of isoflurane.
Materials and Methods: This prospective, randomised, double blind control trial was undertaken in 75 adult patients scheduled for elective laparoscopic surgeries. The subjects were randomly allocated into 3 groups with Group A (2 mg tizanidine), Group B (4 mg tizanidine), Group C (sugar pellet). The study drug was administered orally 90 minutes preoperatively. Intraoperative isoflurane consumption and end tidal isoflurane was recorded.
Results: Demographic data was comparable between the 3 groups. We observed a significant fall in isoflurane consumption in the tizanidine groups [Total: group A = 10.24 (2.07) ml, group B = 8.09 (2.17) ml, group C = 15.43 (4.77), p < 0 xss=removed xss=removed xss=removed xss=removed xss=removed xss=removed xss=removed xss=removed xss=removed> Conclusions: Oral tizanidine [2mg and 4 mg] is as effective and safe anaesthetic premedication in decreasing isoflurane consumption.

Keywords: Alpha 2 agonist, Isoflurane, Laparoscopic, Premedication, Tizanidine.

How to cite : Sanket B , Samudyatha T J, Surhonne N S , Kannan S , Nagaraj S , A randomised controlled double blind study to assess the effect of oral tizanidine premedication on intraoperative isoflurane consumption in patients undergoing laparoscopic surgeries under general anaesthesia. Indian J Clin Anaesth 2021;8(2):214-220

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