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A comparison of dexmedetomidine and clonidine premedication in perioperative hemodynamic stability and postoperative analgesia in laparoscopic cholecystectomy

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Original Article

Author Details : Shreya Sharma, Shashi Prakashi*, Mandeep M H Madia, Vivek Sharma, Chandramani

Volume : 7, Issue : 4, Year : 2020

Article Page : 600-606

https://doi.org/10.18231/j.ijca.2020.109

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Abstract

Background: The aim of this study was to compare dexmedetomidine and clonidine premedication in perioperative hemodynamic stability and postoperative analgesia in laparoscopic cholecystectomy.
Materials and Methods: An observational study was conducted in Sir Sunderlal hospital, Banaras Hindu University. The study included ASA I-II patients undergoing laparoscopic cholecystectomy surgery.
Patients undergoing general anaesthesia were included in the study. The control group received iv fentanyl, while patients in one experimental group received iv clonidine 1mcg/kg over 15 minutes, 30 minutes before and in another group received iv dexmedetomidine 1mcg/kg over 15 minutes, 30 minutes before the surgery. Heart Rate, SBP, MAP, DBP, ETCO2, PCO2 and Post-Operative Analgesia were compared for the 3 groups.
Results were given as mean ± SD. Data collected were analysed using Student’s t-test. Differences were considered statistically significant if P values were <0> Results: A total of 90 patients were included and 30 patients each were randomly assigned to one of the 3 groups. Patients who received dexmedetomidine had better haemodynamic control and post-operative analgesia. Patients who received clonidine had better haemodynamic control than control group but not better than the group who received dexmedetomidine.
Conclusion: We conclude that Alpha 2 agonists specially dexmedetomidine produce diverse responses including analgesia, anxiolysis, sedation and sympatholysis.

Keywords: SBP, DBP, MAP, Laparoscopic surgery, Alpha 2 agonist, Dexmedetomidine, Clonidine, Haemodynamic stability.

How to cite : Sharma S , Prakashi S , Madia M M H , Sharma V , Chandramani, A comparison of dexmedetomidine and clonidine premedication in perioperative hemodynamic stability and postoperative analgesia in laparoscopic cholecystectomy. Indian J Clin Anaesth 2020;7(4):600-606

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