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Glomerular basement membrane damage and leaking of structural proteins in among different stages of type 2 diabetes mellitus patients

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Original Article

Author Details : Raghavendra K, Shantharam V*

Volume : 7, Issue : 3, Year : 2021

Article Page : 73-76

https://doi.org/10.18231/j.ijashnb.2021.019

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Abstract

Background: Type 2 Diabetes mellitus (T2DM) is a syndrome of disorders characterized by hyperglycemia caused due to a relative or absolute deficiency of insulin, decreased glucose utilization. The metabolic derangements in diabetes lead to secondary complications that affect multiple organ systems particularly on kidney. For early detection of kidney damage in T2DM patients are important by using certain type of urinary proteins. We aimed to evaluate the glomerular basement membrane damage and leaking of structural proteins in among different stages of type 2 diabetes mellitus patients.
Materials and Methods: A total 150 type 2 diabetes mellitus patients were included in the present study and again sub classified into 2 types (Normoalbuminuria 50, Microalbuminuria 50) based on their urinary ACR and also included 50 age, gender matched healthy controls. The FBS, PPBS, Urea, Creatinine, HbA1C, Urinary Albumin was analysed by using laboratory standard methods and Urinary Adiponectin was measured by using were collected from the all subjects. A statistical was performed by using SPSS Version 21.0 and P value considers < 0> Results: The significantly elevated levels of plasma FBS, PPBS, Serum Urea, Creatinine, HbA1c, Urinary albuminuria and Urinary Adiponectin observed in two groups of type 2 diabetes mellitus when compared to healthy controls. The Urinary Adiponectin was positively correlated with blood sugar levels and urinary albumin in two groups of diabetes mellitus. The data showed a significantly damaged foot process of podocytes and glomerular basement membrane leads to leaking of certain urinary proteins.
Conclusion: The elevated levels of Urinary Proteins and HbA1c, Urinary Albuminuria directly indicate the damage of podocytes and glomerular basement membrane in the kidney. These studies suggest continuous monitoring of these parameters may helpful for progression of type 2 diabetes mellitus complications.
 
Keywords: Type 2 Diabetes Mellitus, U ACR, HbA1c and U Adiponectin

How to cite : Raghavendra K, Shantharam V, Glomerular basement membrane damage and leaking of structural proteins in among different stages of type 2 diabetes mellitus patients. IP Indian J Anat Surg Head Neck Brain 2021;7(3):73-76

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