Vitamin D Status, Insulin Resistance, Leptin-To-Adiponectin Ratio in Adolescents: Results of a 1-Year Lifestyle Intervention

Authors

  • Christine Rambhojan Equipe de recherche sur le Risque Cardio métabolique, ECM/LAMIA EA4540, Université des Antilles, Guadeloupe
  • Laurent Larifla Equipe de recherche sur le Risque Cardio métabolique, ECM/LAMIA EA4540, Université des Antilles, Guadeloupe
  • Josiane Clepier Réseau GRANDIR, Guadeloupe
  • Elodie Bouaziz-Amar Sorbonne Université, UPMC Univ Paris 06, UMR_S 1166, ICAN, F-75005, INSERM, UMR_S 1166, ICAN, F-75005; INSERM, UMR_S 1166, ICAN, F-75005; AP-HP, Hôpital Pitié-Salpêtrière-Charles Foix, Biochimie Endocrinienne et Oncologique, F-75651
  • Fritz-Line Velayoudom-Cephise Equipe de recherche sur le Risque Cardio métabolique, ECM/LAMIA EA4540, Université des Antilles, Guadeloupe
  • Anne Blanchet-Deverly Equipe de recherche sur le Risque Cardio métabolique, ECM/LAMIA EA4540, Université des Antilles, Guadeloupe
  • Christophe Armand Equipe de recherche sur le Risque Cardio métabolique, ECM/LAMIA EA4540, Université des Antilles, Guadeloupe; Département de Santé Publique, CHU 97159 Pointe-à-Pitre, Guadeloupe
  • Jean Plumasseau Centre d’Examens de Santé, AGREXAM, Guadeloupe
  • Jean-Marc Lacorte Sorbonne Université, UPMC Univ Paris 06, UMR_S 1166, ICAN, F-75005, INSERM, UMR_S 1166, ICAN, F-75005; INSERM, UMR_S 1166, ICAN, F-75005; AP-HP, Hôpital Pitié-Salpêtrière-Charles Foix, Biochimie Endocrinienne et Oncologique, F-75651
  • Lydia Foucan CHU de Guadeloupe, Public Health; Equipe de recherche sur le Risque Cardio métabolique, ECM/LAMIA EA4540, Université des Antilles, Guadeloupe

DOI:

https://doi.org/10.3889/oamjms.2016.131

Keywords:

Vitamin D deficiency, Insulin resistance, Leptin-to-adiponectin ratio, Adolescents, Lifestyle intervention

Abstract

AIM: We aimed to study the relationships between circulating 25-hydroxyvitamin D [25(OH)D], insulin resistance and leptin-to-adiponectin (L/A) ratio in Guadeloupean children and adolescents and to analyse the changes in 25(OH)D levels after a 1-year lifestyle intervention program.

METHODS: 25(OH)D concentrations were measured via a chemiluminescence assay. Cardiometabolic risk factors, homoeostasis model assessment of insulin resistance (HOMA-IR), and adipokines were measured. The lifestyle intervention included dietary counselling, regular physical activity.

RESULTS: Among 117 girls and boys (11–15 years old, 31.6% obese), 40% had vitamin D deficiency (25(OH)D levels < 20 ng/mL). With linear regression models where 25(OH)D and HOMA-IR acted as independent variables and age, sex, BMI, L/A ratio as covariates, 25(OH)D was significantly associated with HOMA-IR alone (P = 0.036). HOMA-IR was also associated with BMI z-score ≥ 2, L/A ratio and an interaction term BMI z-score ≥ 2*L/A ratio (P < 0.001 for all). After one year, in 78 children/adolescent, mean serum 25(OH)D increased significantly from 21.4 ± 4.9 ng/mL at baseline to 23.2 ± 6.0 after 1 year; P = 0.003 whereas BMI z-score, HOMA-IR and L/A ratio decreased significantly (P = 0.003, P < 0.001 and P = 0.012; respectively).

CONCLUSION: The association between 25(OH)D and HOMA-IR, independently of obesity and the high prevalence of vitamin D deficiency should be considered in order to prevent the later incidence of T2DM. A healthy lifestyle including non-sedentary and outdoor activities could be a way for improving vitamin D status.

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Published

2016-12-08

How to Cite

1.
Rambhojan C, Larifla L, Clepier J, Bouaziz-Amar E, Velayoudom-Cephise F-L, Blanchet-Deverly A, Armand C, Plumasseau J, Lacorte J-M, Foucan L. Vitamin D Status, Insulin Resistance, Leptin-To-Adiponectin Ratio in Adolescents: Results of a 1-Year Lifestyle Intervention. Open Access Maced J Med Sci [Internet]. 2016 Dec. 8 [cited 2024 May 22];4(4):596-602. Available from: https://oamjms.eu/index.php/mjms/article/view/oamjms.2016.131

Issue

Vol. 4 No. 4 (2016): Dec 15 (OAMJMS)

Section

A - Basic Science

License

http://creativecommons.org/licenses/by-nc/4.0

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