Protective Effects of Berberis vulgaris on Diazinon-Induced Brain Damage in Young Male Mice

Azadeh Sonei; Simin Fazelipour; Leila Kanaani; Mahsa Hadipour Jahromy

doi:10.3746/pnf.2020.25.1.65

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저널정보

한국식품영양과학회
Preventive Nutrition and Food Science 학술저널
Preventive Nutrition and Food Science Vol.25 No.1
2020.3 65 - 70 (6page)
DOI : 10.3746/pnf.2020.25.1.65

저자정보

Azadeh Sonei (Islamic Azad University)
Simin Fazelipour (Islamic Azad University)
Leila Kanaani (Islamic Azad University)
Mahsa Hadipour Jahromy (Islamic Azad University)

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Diazinon is an imminent and hazardous chemical organophosphate multiplex that is generally used as a pesticide but is toxic for many species particularly vertebrates. Berberry (Berberis vulgaris L., family Berberidaceae) is a plant that flourishes in Europe and Asia that has been largely investigated for its therapeutic effects. In the present study, we evaluated the protective effects of B. vulgaris on diazinon-induced brain damage in young male mice. Twenty-one young male albino mice weighing 18±2 g were divided in three equal groups of seven mice, and treated orally with either olive oil (control), diazinon 50 mg/kg+B. vulgaris extract 200 mg/kg, or diazinon 50 mg/kg. After three weeks, cerebrum and cerebellum samples were collected for antioxidant assays. The results indicated that diazinon increased oxidative stress in the brain of mice. The glutathione content and proceedings of antioxidant enzymes, such as glutathione peroxidase, superoxide dismutase, and catalase, were significantly reduced in both the cerebellum and cerebrum of diazinon-treated mice, compared with the control group. In addition, acetylcholinesterase (AChE) activity was inhibited by exposure to this pesticide. Administration of 200 mg/kg B. vulgaris extract with diazinon significantly decreased oxidative stress indices in all experiments. The results indicated that B. vulgaris extract has protective effects against lipid peroxidation of the cerebellum and cerebrum, and in regenerating AChE activity in the brain induced by diazinon.

#Berberis vulgaris #brain damage #diazinon #mice