YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
誌上シンポジウム
超高分子多糖類サクランの一軸配向膜形成と薬物放出の試み
桶葭 興資岡島 麻衣子金子 達雄
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2018 年 138 巻 4 号 p. 503-507

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 The geometric structures of soft materials can be controlled on the macro-scale using interfacial or mechanical instability, e.g., fingering patterns of viscous liquid and buckling patterns of gels during swelling/deswelling. These patterns can be used as smart materials for capturing/releasing and mass-transportation applications. Here we introduce the emergence of a uniaxially oriented membrane by drying an aqueous liquid-crystalline solution, composed of megamolecular supra-polysaccharides “sacran”, from a limited space. By controlling the geometries of the evaporation front, multiple nuclei emerge that grow into upright membranes with uniaxial orientation. Notably, the uniaxially orientated membrane composed of rod-like microdomains is rationally formed along the dynamic three-phase contact line. Besides, the membrane macroscopically partitions the three-dimensional cuboid cell for evaporating the aqueous solution. We envision that such a uniaxially oriented membrane can be used as soft biomaterials such as dialysis membranes with directional controllability in medical and pharmaceutical fields.

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© 2018 The Pharmaceutical Society of Japan
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