Abstract
Ayahuasca is a herbal brew that is widespread in Indigenous Upper Amazon and has undergone global expansion in the last decade. As it is taken up in an ever-growing range of ritual or experimental practices questions of authority, authenticity, propriety or safety become acute. This case allows us to interrogate contemporary processes of value-making as radically different and highly stratified values encounter each other, on the brink of a possible pharmaceuticalization of ayahuasca. I argue that ayahuasca is not fully captured by the value logics of capital and examine the ways in which its promissory dimensions, global circulation and entry into practices of biomedical evidence-making position it in an ambiguous space that is nevertheless not entirely outside the logics of capital. The circuits of ayahuasca’s valorization reveal a complex coproduction of value that makes strategic use of various scales, sites and situations. The article examines the promissory horizon of extra-pharmacological value identified as key to understanding the efficacy of psychedelic substances such as ayahuasca. It then attends to the extraction of value from plants before closing with a reflexion on the politics of inclusion in the discussions that frame ayahuasca’s value globally.
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Notes
The first (2014) and third (2019) of these events were held in Spain while the second (2016) brought together some 600 Indigenous leaders, ritual specialists, anthropologists, historians, psychologists, legal scholars, clinicians, artists, and enthusiasts gathered in the Amazonian city of Rio Branco, Brazil.
Conference program and recordings available at https://chacruna.net/psychedelic-liberty-summit/ (accessed 8th July 2020).
For reasons of space, and in consideration of ethical questions regarding the uncertain legal status of these market operations, I do not engage an analysis of how the markets for plant materials themselves engage or disrupt the value logics of capital.
http://www.theonion.com/article/ayahuasca-shaman-dreading-another-week-guiding-tec-52941 (accessed 6th April 2017).
Further details available here: https://maps.org/research/mdma/ptsd/phase3 (accessed 8th July 2020).
The study is a neuropharmacological experiment into changes in the brain blood flow, electrical activity and network communication patterns of research subjects under the influence of the psychedelic compound LSD. It revealed, experimentally, a series of patterns in subjects’ brain structure that account for the therapeutic potential of psychedelic compounds which are understood to trigger hyper-emotional and imaginative states conducive to a “re-setting”.
Source: https://investingnews.com/daily/life-science-investing/psychedelics-investing/ways-to-invest-in-psychedelics/ other examples: https://www.fool.com/investing/2020/02/29/forget-cannabis-psychedelic-medicine-is-the-better.aspx (both accessed 8th July 2020).
33% of the patients in placebo arm believed they were in the active arm of the trial, two even vomited and one had diarrhoea.
For a study on the variability of the chemical composition of ayahuasca brews see Kaasik et al. (2020).
These are translations from my hand written notes, not exact transcripts as recording in this vast auditorium was near impossible.
Interestingly, the Third World Ayahuasca Conference was held in Spain and although the conference organizers opened space for an autonomous Indigenous delegation, this had the unwitting effect of positioning Indigenous questions outside the main conference stages. The Indigenous declaration is accessible here: https://www.ayaconference.com/declaration-by-the-indigenous-peoples-and-nations-of-the-amazon-basin/
References
Ahmed, Sara. 2006. Orientations: Toward a Queer Phenomenology. Durham: Duke University Press.
Assis, Glauber Loures, and Jacqueline Alves Rodrigues. 2018. Uma Bebida, Muitas Visões: Apontamentos Sociológicos Sobre a II Conferência Mundial Da Ayahuasca. Horizontes Antropológicos 24 (51): 135–165.
Barry, Andrew. 2005. Pharmaceutical Matters; The Invention of Informed Materials. Theory, Culture & Society 22 (1): 51–69.
Basu, Tanya. 2016. The 2016 Experiment of the Year. Inverse Science.
Benjamin, De Loenen, Oscar Pares Franquero, and Constanza Sanchez Avilés. 2017. A Climate for Change: ICEERS and the Challenges of the Globalization of Ayahuasca. In The World Ayahuasca Diaspora: Reinventions and Controversies, ed. B. Labate, C. Cavnar, and Gearin, A., 224–241. London: Routledge.
Bensaude-Vincent, Bernadette, and Isabelle Stengers. 1992. Histoire de La Chimie. Paris: La Découverte.
Boyer, Dominic. 2008. Thinking Through the Anthropology of Experts. Anthropology in Action 15 (2): 38–46.
Bustos, Susana. 2008. The Healing Power of the Icaros: A Phenomenological Study of Ayahuasca Experiences. San Francisco: California Institute of Integral Studies.
Carhart-Harris, Robin L., Robert Leech, Peter J. Hellyer, et al. 2014. The Entropic Brain: A Theory of Conscious States Informed by Neuroimaging Research with Psychedelic Drugs. Frontiers in Neuroscience 8 (20).
Craig, Sienna. 2012. Healing Elements: Efficacy and the Social Ecologies of Tibetan Medicine. Berkeley and London: University of California Press.
Dawson, Andrew. 2013. Santo Daime: A New World Religion. London: Bloomsbury.
de Dobkin Rios, Marlene. 1984. Visionary Vine : Hallucinogenic Healing in the Peruvian Amazon. Long Grove: Waveland Press.
De la Cadena, Marisol. 2015. Earth Beings: Ecologies of Practice Across Andean Worlds. Durham, NC: Duke University Press.
dos Santos, Rafael G., José C. Bouso, and Jaime E. Hallak. 2020. Hallucinogens/Psychedelics Resurrected as New Tools in Psychiatric Therapy. Brazilian Journal of Psychiatry 00 (00): 1–2.
dos Santos, Rafael G., Flávia. L. Osório, José Alexandre, S. Crippa, and Jaime E. C.. Hallak. 2016. Antidepressive and Anxiolytic Effects of Ayahuasca: A Systematic Literature Review of Animal and Human Studies. Revista Brasileira de Psiquiatria 38 (1): 65–72.
Doyle, Richard. 2002. LSDNA: Rhetoric, Consciousness Expansion, and the Emergence of Biotechnology. Philosophy & Rhetoric 35 (2): 153–174.
Dumit, Joseph. 2012. Drugs for Life: How Pharmaceutical Companies Define Our Health. Durham, NC: Duke University Press.
Farquhar, J., and L. Lai. 2014. Information and Its Practical Other: Crafting Zhuang Nationality Medicine. East Asian Science, Technology and Society 8 (4): 417–437.
Fortun, Kim. 2001. Advocacy After Bhopal: Environmentalism, Disaster, New Global Orders. Chicago: University of Chicago Press.
Foster, Laura. 2016. The Making and Unmaking of Patent Ownership: Technicalities, Materialities, and Subjectivities. POLAR Political and Legal Anthropology Review 39 (1): 127–143.
Fotiou, Evgenia. 2018. Plant Use and Shamanic Dietas in Contemporary Ayahuasca Shamanism in Peru. In Ethnopharmacologic Search for Psychoactive Drugs: 50 Years of Research (1967–2017), ed. D. McKenna, 55–69. Santa Fe: Synergetic Press.
Gaudillière, Jean-Paul., and Volker Hess. 2013. Ways of Regulating Drugs in the 19th and 20th Centuries. London: Palgrave Macmillan.
Gaudillière, Jean-Paul., and Laurent Pordié. 2014. The Reformulation Regime in Drug Discovery: Revisiting Polyherbals and Property Rights in the Ayurvedic Industry. East Asian Science, Technology and Society: An International Journal 8: 57–79.
Gaudilliere, J.-P. 2014. An Indian Path to Biocapital? The Traditional Knowledge Digital Library, Drug Patents, and the Reformulation Regime of Contemporary Ayurveda. East Asian Science, Technology and Society 8 (4): 391–415.
Haase, Rachel, Marsha Michie, and Debra Skinner. 2015. Flexible Positions, Managed Hopes: The Promissory Bioeconomy of a Whole Genome Sequencing Cancer Study. Social Science & Medicine 130 (1): 146–153.
Haraway, Donna. 1991. Simians, Cyborgs and Women: The Reinvention of Nature. London: Free Association Books.
Hayden, Cori. 2003. When Nature Goes Public: The Making and Unmaking of Bioprospecting in Mexico. Princeton: Princeton University Press.
Holmes, Douglas R., and George E. Marcus. 2008. Collaboration Today and the Re-Imagination of the Classic Scene of Fieldwork Encounter. Collaborative Anthropologies 1: 81–101.
Hsu, Elisabeth. 2012. Plants in Medical Practice and Common Sense: On the Interface of Ethnobotany and Medical Anthropology. In Plants, Health and Healing: On the Interface of Ethnobotany and Medical Anthropology, ed. E. Hsu and S. Harris, 1–48. New York: Berghahn Books.
Hsu, Elisabeth, and Stephen Harris. 2010. Plants, Health and Healing: On the Interface of Ethnobotany and Medical Anthropology. New York and Oxford: Berghahn Books.
Inserra, Antonio. 2018. Hypothesis: The Psychedelic Ayahuasca Heals Traumatic Memories via a Sigma 1 Receptor-Mediated Epigenetic-Mnemonic Process. Frontiers in Pharmacology 9: 1–13.
Jasanoff, Sheila. 2004. States of Knowledge: The Co-Production of Science and the Social Order. London and New York: Routledge.
Jiménez-Garrido, Daniel F., María Gómez-Sousa, Genís Ona, et al. 2020. Effects of Ayahuasca on Mental Health and Quality of Life in Naïve Users: A Longitudinal and Cross-Sectional Study Combination. Scientific Reports 10 (1): 1–12.
Kaasik, Helle, Rita C.Z. Souza, and Flávia S. Zandonadi, Luís Fernando Tófoli, and Alessandra Sussulini, 2020. Chemical Composition of Traditional and Analog Ayahuasca. Journal of Psychoactive Drugs. https://doi.org/10.1080/02791072.2020.1815911.
Labate, Beatriz, and Clancy Cavnar. 2014. Ayahuasca Shamanism in the Amazon and Beyond. Oxford: Oxford University Press.
Labate, Beatriz, and Ilana Goldstein. 2009. Ayahuasca - From Dangerous Drug to National Heritage: An Interview with Antonio A. Arantes. International Journal of Transpersonal Studies 28: 53–64.
Labate, Beatriz, and Henrik Jungaberle. 2011. The Internationalization of Ayahuasca. Berlin: LIT Verlag.
Labate, Beatriz, and Glauber Loures de Assis. 2017. The Religion of the Forest: Reflections on the International Expansion of a Brazilian Ayahuasca Religion. In The World Ayahuasca Diaspora: Reinventions and Controversies, ed. B.C. Labate, C. Cavnar, and A. Gearin, 57–78. London and New York: Routledge.
Labate, Beatriz, and Edward MacRae. 2010. Ayahuasca, Ritual and Religion in Brazil. London and New York: Routledge.
Lai, Lili, and Judith Farquhar. 2015. Nationality Medicines in China: Institutional Rationality and Healing Charisma. Comparative Studies in Society and History 57 (02): 381–406.
Langwick, Stacey A. 2015. Partial Publics: The Political Promise of Traditional Medicine in Africa. Current Anthropology 56 (4): 493–514.
Laplante, Julie. 2015. Healing Roots: Anthropology in Life and Medicine. New York and Oxford: Berghahn.
Leary, Timothy, and Ralph Metzner. 1967. On Programming Psychedelic Experiences. Psychedelic Review 9: 5–19.
Levis, C., F.R.C. Costa, F. Bongers, et al. 2017. Persistent Effects of Pre-Columbian Plant Domestication on Amazonian Forest Composition. Science 355 (6328): 925–931.
Liester, Mitchell B., and James I. Prickett. 2012. Hypotheses Regarding the Mechanisms of Ayahuasca in the Treatment of Addictions. Journal of Psychoactive Drugs 44 (3): 200–208.
Loizaga-Velder, Anja, and Rolf Verres. 2014. Therapeutic Effects of Ritual Ayahuasca Use in the Treatment of Substance Dependence-Qualitative Results. Journal of Psychoactive Drugs 46 (1): 63–72.
Marcus, George. 2013. Experimental Forms for the Expression of Norms in the Ethnography of the Contemporary. HAU: Journal of Ethnographic Theory. https://doi.org/10.14318/hau3.2.011.
Martin, Paul, Nik Brown, and Andrew Turner. 2008. Capitalizing Hope: The Commercial Development of Umbilical Cord Blood Stem Cell Banking. New Genetics and Society: Critical Studies of Contemporary Biosciences 27 (2): 127–143.
Mesturini Cappo, Silvia. 2018. What Ayahuasca Wants: Notes for the Study and Preservation of an Entangled Ayahuasca. In The Expanding World Ayahuasca Diaspora, ed. Beatriz Labate and Clancy Cavnar, 157–176. London: Routledge.
Mol, Annemarie. 2002. The Body Multiple: Ontology in Medical Practice. Durham, NC: Duke University Press.
Onion. 2016. Ayahuasca Shaman Dreading Another Week Of Guiding Tech CEOs To Spiritual Oneness. The ONION 52: 19.
Palhano-Fontes, Fernanda, Dayanna Barreto, Heloisa Onias, et al. 2019. Rapid Antidepressant Effects of the Psychedelic Ayahuasca in Treatment-Resistant Depression: A Randomized Placebo-Controlled Trial. Psychological Medicine 49 (4): 655–663.
Peterson, Kristin. 2014. Speculative Markets: Drug Circuits and Derivative Life in Nigeria. Durham, NC: Duke University Press.
Petryna, Adriana, Arthur Kleinman, and Andrew Lakoff. 2006. Global Pharmaceuticals: Ethics, Markets, Practices. Durham, NC: Duke University Press.
Povinelli, Elizabeth. 2011. Economies of Abandonment: Social Belonging and Endurance in Late Liberalism. Durham, NC: Duke University Press.
Rival, Laura. 2006. Amazonian Historical Ecologies. Journal of the Royal Anthropological Institute 12 (s1): S79–S94.
Sanches, Rafael Faria, Flávia. de Lima, Rafael G. Osório, Dos Santos, et al. 2016. Antidepressant Effects of a Single Dose of Ayahuasca in Patients With Recurrent Depression: A SPECT Study. Journal of Clinical Psychopharmacology 36 (1): 77–81.
Schindler, Emmanuelle, Ryan Wallace, Jordan Sloshower, and Deepak D’Souza. 2018. Neuroendocrine Associations Underlying the Persistent Therapeutic Effects of Classic Serotonergic Psychedelics. Frontiers in Pharmacology 9: 177.
Sessa, Ben. 2012. Shaping the Renaissance of Psychedelic Research. The Lancet 380 (9838): 200–201.
Shepard, Glenn. 2017. Forward. Ayahuasca in the Twenty-First Century: Having It Both Ways. In The World Ayahuasca Diaspora: Reinventions and Controversies, xv–xix. London and New York: Routledge.
Steinhardt, Joanna, and Tehseen Noorani. 2020. The Psychedelic Revival. Hot Spots, Fieldsites. https://culanth.org/fieldsights/series/the-psychedelic-revival, accessed October 8, 2020.
Strathern, Marilyn. 2005. Partial Connections. Updated. London: Rowman & Littlefield.
Suárez Álvarez, Carlos. 2019. Ayahuasca, Iquitos and Monster Vorax. http://www.ayahuascaiquitos.com/en/index.php/2019-05-07-19-55-48/book-ii-a-cash-crop.
Sunder Rajan, Kaushik. 2005. Biocapital: The Constitution of Post-Genomic Life. Durham NC: Duke University Press.
Sunder Rajan, Kausik. 2017. Pharmocracy: Trials of Global Biomedicine. Durham, NC: Duke University Press.
Szabo, Attila. 2015. Psychedelics and Immunomodulation: Novel Approaches and Therapeutic Opportunities. Frontiers in Immunology 6: 358.
Talin, Piera, and Emilia Sanabria. 2017. Ayahuasca’s Entwined Efficacy: An Ethnographic Study of Ritual Healing from ‘Addiction.’ International Journal of Drug Policy 44: 23–30.
Taussig, Michael T. 1987. Shamanism, Colonialism, and the Wild Man: A Study in Terror and Healing. Chicago and London: University of Chicago Press.
Thomas, Gerald, N. Philippe Lucas, Rielle Capler, Kenneth W. Tupper, and Gina Martin. 2013. Ayahuasca-Assisted Therapy for Addiction: Results from a Preliminary Observational Study in Canada. Current Drug Abuse Reviews 6 (1): 30–42.
Tofoli, Luis F. 2019. How Many Ayahuasca Drinkers Are There in Brazil? Chacruna, November 8. https://chacruna.net/how-many-ayahuasca-drinkers-are-there-in-brazil/, accessed October 6, 2020.
Tupper, Kenneth W., and Beatriz C. Labate. 2014. Ayahuasca, Psychedelic Studies and Health Sciences: The Politics of Knowledge and Inquiry into an Amazonian Plant Brew. Current Drug Abuse Reviews 7 (2): 71–80.
Tym, Christian. 2020. Medicine as Microcosm: Pharmaceutical Bioprospecting and the Political Epistemology of Nature in Industrial-Capitalist and Indigenous Amazonian Societies. Environment and Planning E Nature and Space 1 (1): 25–43.
Viveiros de Castro, Eduardo. 2004. Perspectival Anthropology and the Method of Controlled Equivocation. Tipití: Journal of the Society for the Anthropology of Lowland South America 2(1). http://digitalcommons.trinity.edu/tipiti.
Wahlberg, Ayo. 2014. Herbs, Laboratories, and Revolution: On the Making of a National Medicine in Vietnam. East Asian Science, Technology and Society 8 (1): 43–56.
Zhan, Mei. 2018. Cosmographic Experiments: Thinking, Doing, and Being with Classical Chinese Medicine. Humanities Futures Online
Acknowledgements
This research was made possible by generous support from the ERC Starting Grant no. 757589 “HealingEncounters” based at CERMES3 (Université de Paris, EHESS, CNRS). I am grateful to the participants of the Making of Pharmaceutical Value: Drugs, Diseases and the Political Economies of Global Health workshop held in Paris in June 2016, in particular Thomas Cousins, Jean-Paul Gaudillière, Kristin Peterson and Kaushik Sunder Rajan. Special thanks to Piera Talin and Clayton França for the discussions that took root in Rio Branco, and to Joseph Dumit for the all the inspiring conversations that have shaped my thinking; as well as to the three anonymous reviewers who provided valuable—no pun intended—feedback on earlier versions of the argument.
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Sanabria, E. Vegetative value: promissory horizons of therapeutic innovation in the global circulation of ayahuasca. BioSocieties 16, 387–410 (2021). https://doi.org/10.1057/s41292-020-00222-4
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DOI: https://doi.org/10.1057/s41292-020-00222-4