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MicroRNA and signaling pathways in gastric cancer

Cancer Gene Therapy volume 21, pages 305–316 (2014)Cite this article

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Abstract

MicroRNAs (miRNAs) function as either oncogenes or tumor suppressors by inhibiting the expression of target genes, some of which are either directly or indirectly involved with canonical signaling pathways. The relationship between miRNAs and signaling pathways in gastric cancer is extremely complicated. In this paper, we determined the pathogenic mechanism of gastric cancer related to miRNA expression based on recent high-quality studies and then clarified the regulation network of miRNA expression and the correlated functions of these miRNAs during the progression of gastric cancer. We try to illustrate the correlation between the expression of miRNAs and outcomes of patients with gastric cancer. Understanding this will allow us to take a big step forward in the treatment of gastric cancer.

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  1. Department of Oncological Surgery, Affiliated Hospital of Hebei University, Baoding, China

    Z Zhang, Z Li & A Zang

  2. Department of Gastric Cancer, Fourth Hospital of Hebei Medical University, Shijiazhuang, China

    Y Li

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Zhang, Z., Li, Z., Li, Y. et al. MicroRNA and signaling pathways in gastric cancer. Cancer Gene Ther 21, 305–316 (2014). https://doi.org/10.1038/cgt.2014.37

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