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Same same but different: Wie Cyanobakterien ein zentrales Enzym regulieren

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Abstract

In most bacteria the activity of glutamine synthetase (GS) is regulated by covalent protein modifications. Remarkably, cyanobacteria, which are of increasing interest in biotechnology, have evolved fundamentally different regulatory mechanisms for the same enzyme. This includes GS inhibition by the interaction with small proteins, the inactivating factors (IF). In addition, they evolved unique mechanisms to monitor GS activity and to respond with IF biosynthesis accordingly.

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Authors and Affiliations

  1. Department für Solare Materialien AG Molecular Biology of Cyanobacteria, Helmholtz-Zentrum für Umweltforschung - UFZ, Permoserstraße 15, D-04318, Leipzig, Deutschland

    Stephan Klähn

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  1. Stephan Klähn
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Correspondence to Stephan Klähn.

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Stephan Klähn 2001–2006 Biologiestudium an der Universität Rostock; dort 2010 Promotion. 2010–2018 Postdoc und wissenschaftlicher Mitarbeiter an der Universität Freiburg. Forschungsaufenthalte an der Yale University und Oklahoma State University, USA, und am Qingdao Institute of Bioenergy and Bioprocess Technology, China. Seit 2018 Gruppenleiter am Helmholtz-Zentrum für Umweltforschung - UFZ, Leipzig. 2019 Habilitation. Seit 2019 Sprecher der VAAM-Fachgruppe Cyanobakterien.

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Klähn, S. Same same but different: Wie Cyanobakterien ein zentrales Enzym regulieren. Biospektrum 25, 610–613 (2019). https://doi.org/10.1007/s12268-019-0208-x

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  • DOI: https://doi.org/10.1007/s12268-019-0208-x

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