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Preventive effects of the extract of kinka-cha, a folk tea, on a rat model of metabolic syndrome

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Abstract

Kinka-cha (dried leaf of Camellia nitidissima) is used as a folk tea for detoxication, diuresis and antihypertension. In the present study, we evaluated the extract of kinka-cha on metabolic, vascular and oxidative stress parameters in a model of metabolic syndrome, SHR/NDmcr-cp/cp (SHR/cp) rats that manifest hypertension, obesity, glucose intolerance and hyperlipidemia. Treatment with the extract of kinka-cha alleviated the increase in blood pressure, decrease in tail blood flow and elevated serum oxidative stress marker levels including lipid peroxides, 8-hydroxy-2′-deoxyguanosine, 3-nitrotyrosine and 3-chlorotyrosine. However, kinka-cha did not affect weight gain, hyperglycemia and hyperlipidemia, nor the relaxation responses of the aorta mesenteric artery, thoracic aortas and tail vein, and blood clotting and platelet aggregation. These results suggest that kinka-cha can help reduce the risk of developing metabolic syndrome, possibly due to the presence of antioxidants.

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Acknowledgments

This research was supported by the Open Research Center Project of Mukogawa Women’s University for studying lifestyle-related disease, Japan.

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Authors and Affiliations

  1. School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women’s University, 11-68 Koshien Kuban-cho, Nishinomiya, 663-8179, Japan

    Hisae Oku, Yuko Ogawa, Emiko Iwaoka, Yu Yamaguchi, Satomi Kagota, Shinozuka Kazumasa, Masaru Kunitomo & Kyoko Ishiguro

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  1. Hisae Oku
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  2. Yuko Ogawa
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  3. Emiko Iwaoka
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  4. Yu Yamaguchi
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  5. Satomi Kagota
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  6. Shinozuka Kazumasa
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  7. Masaru Kunitomo
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  8. Kyoko Ishiguro
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Correspondence to Kyoko Ishiguro.

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Oku, H., Ogawa, Y., Iwaoka, E. et al. Preventive effects of the extract of kinka-cha, a folk tea, on a rat model of metabolic syndrome. J Nat Med 65, 610–616 (2011). https://doi.org/10.1007/s11418-011-0523-0

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  • DOI: https://doi.org/10.1007/s11418-011-0523-0

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