Abstract
Purpose
The aim of this study is to evaluate the incidence of consecutive strabismus after infantile nystagmus surgery and its potential risk factors.
Methods
A retrospective study including 89 patients was conducted. Patients presented infantile nystagmus (idiopathic or ocular disease–associated nystagmus) without previous or coincidental strabismus. Sex, age at surgery, amblyopia, botulinum toxin (BT) injection before surgery, spherical equivalent, anisometropia, surgery procedure (Anderson’s or retroequatorial recessions of four horizontal recti), and follow-up were analyzed. Kaplan-Meier and univariate Cox regression were performed.
Results
The median age at surgery was 5 years. The median follow-up was 36 months. The incidence of consecutive strabismus was 11.2%. There were eight patients with exotropia and two patients with esotropia. Consecutive strabismus was associated with severe bilateral amblyopia (p = 0.036), previous treatment with BT injection (p = 0.025), and large recessions of the four horizontal muscles (p = 0.001). The hazard ratio for patients with severe bilateral amblyopia was 5.4 (95% CI 1.1–25.8), and for patients previously treated with BT was 6.1 (1.3–29.3). The survival rate was 95.4% at 6 months and 88.5% at 3 years.
Conclusion
Severe bilateral amblyopia, previous BT treatment, and type of surgery seem to be associated with consecutive strabismus after infantile nystagmus surgery. Most cases appear within the first months after surgery.
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All procedures performed in the study were in accordance with the ethical standards of Institutional Research Ethics Committee of Ramón y Cajal University Hospital and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Due to the retrospective nature of the study, informed consent was not required.
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Gómez-Mariscal, M., Hernández-Martínez, P., Rodríguez-del Valle, J.M. et al. Consecutive strabismus after infantile nystagmus syndrome surgery and potential risk factors. Graefes Arch Clin Exp Ophthalmol 258, 1549–1554 (2020). https://doi.org/10.1007/s00417-020-04686-9
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DOI: https://doi.org/10.1007/s00417-020-04686-9