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Prognostic significance of parameters from pretreatment 18F-FDG PET in hepatocellular carcinoma: a meta-analysis

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Abstract

Purpose

The prognostic value of 18F-deoxyglucose positron emission tomography (18F-FDG PET) on hepatocellular carcinoma (HCC) remains inconclusive. This study aims to investigate the prognostic role of pretreatment 18F-FDG PET on HCC patients by meta-analysis.

Methods

PubMed, Embase, Cochrane library, and Wanfang databases were searched until June 2015. Hazard ratios (HRs) with corresponding 95% confidence intervals (CIs) were synthesized by Stata 10.0, and the combined results were used as effective values.

Results

Twenty-two studies containing a total of 1721 patients were identified. According to random-effect model, meta-analysis results showed that high Tumor SUV/Liver SUV (Tsuv/Lsuv) ratio was significantly associated with poorer overall survival (OS) (HR = 2.04; 95% CI 1.50–2.79; P = 0.000) and poorer disease-free survival (HR = 7.17; 95% CI 3.58–14.36; P = 0.000); and high Tumor SUV (Tsuv) value was also correlated with poor OS (HR = 1.53; 95% CI 1.26–1.87; P = 0.000). Meanwhile, subgroup analysis results showed that the significant association above was not altered by study sample size, parameter cutoff value, analytic method, and follow-up period, but there was no significant association between Tsuv/Lsuv ratio and OS in patients who underwent resection (HR = 1.71; 95% CI 1.00–2.92; P = 0.052).

Conclusions

Both high Tsuv/Lsuv ratio and high Tsuv value are associated with poor prognosis in HCC patients. Therefore, pretreatment 18F-FDG PET is a useful tool in predicting the prognosis of HCC patients. More studies with explicit treatment modalities are required to investigate the prognostic value of pretreatment 18F-FDG PET on HCC patients.

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Acknowledgments

This work was supported by research funding from Jilin Provincial Science & Technology Department (No. 20130413021GH).

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    Authors and Affiliations

    1. Department of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin University, Changchun, 130021, Jilin, China

      Da-Wei Sun, Feng Wei, Xiao-Ju Shi, Chuan-Lei Wang, Zheng-Wei Zhao, Teng-Fei Li & Guo-Yue Lv

    2. Department of Dermatology, China-Japan Union Hospital of Jilin University, Changchun, 130033, Jilin, China

      Lin An

    3. Department of Radiology, The First Hospital of Jilin University, Changchun, 130021, Jilin, China

      Lin Mu

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    Da-wei Sun and Lin An have contributed equally to this work.

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    Sun, DW., An, L., Wei, F. et al. Prognostic significance of parameters from pretreatment 18F-FDG PET in hepatocellular carcinoma: a meta-analysis. Abdom Radiol 41, 33–41 (2016). https://doi.org/10.1007/s00261-015-0603-9

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