Abstract
A comparative study was performed on the kinetic properties and the specificity ofd-alanyl-d-alanine ligases fromPseudomonas aeruginosa, Streptococcus faecalis, andStaphylococcus aureus, using some aminophosphonic acids and related compounds.dl-I-Aminoethylphosphonic acid was shown to be a competitive inhibitor of theP. aeruginosa andS. faecalis ligases; assuming ad-form stereospecificity, its activity was nearly equal to that ofd-cycloserine. 2-Aminoethylphosphonate was found to be a weak inhibitor of the ligases, in contrast to the carboxylic analog, β-alanine. γ-Aminobutyric acid and phosphoethanolamine also exhibited some inhibitory properties.
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Lacoste, AM., Poulsen, M., Cassaigne, A. et al. Inhibition ofd-alanyl-d-alanine ligase in different bacterial species by amino phosphonic acids. Current Microbiology 2, 113–117 (1979). https://doi.org/10.1007/BF02603067
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DOI: https://doi.org/10.1007/BF02603067