DescriptionApproximately 50% of cancer patients experience pain even when they take standard pain medications. These pain medications have many side effects, like headache, vomiting, and addiction. Complementary or alternative medicine have become increasingly popular in the US. Complementary or alternative medicine therapies are defined as replacing of or combining with primary care. Complementary or alternative medicine therapies such as auricular acupressure (AA) may decrease medical costs by reducing doctor’s visit and usage of pain medication. The ear acupoints may be stimulated by pressure from fingers, hands, or automatically by the seeds themselves. The basic theory behind AA is that the outer ear, brain, and every part of body are connected by nerve system. When a patient stimulates auricular acupoints, the body produces some opioid substances and hormones or increases anti-inflammatory reaction. Auricular acupressure intervention may empower cancer patients to increase their pain self- management because they need to self-administer AA at their home. Cancer patients may well self-administer AA therapy if they get supported by healthcare providers. There are few studies that have assessed the effect of AA on cancer pain. The purpose of this study is to evaluate the feasibility and effect of AA intervention on cancer patients experiencing pain. One group repeated measure and five visits in time to evaluate retention, adherence, and completion of AA therapy and to assess alleviating cancer pain by an AA intervention. This study was done at Rutgers University and participants’ home. The participants were withdrawn at 33% in the study, adhered to this AA intervention at 99.4% and completed the AA intervention at 100%. The pain severity, pain interference, and the neuropathic pain showed a statistically significant decrease throughout the 4-week AA intervention. As pain severity and pain interference improved in this study, body pain and physical component in quality of life had also improved during the AA intervention period. However, the depression score did not show a statistically significant improvement in this study. Further research with AA therapy with bigger sample size and robust research design is required to build on the evidence on the feasibility and the effect of AA intervention.