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New Plant Species Showing Antiprotozoian Activity

  • BIOCHEMISTRY, BIOPHYSICS, AND MOLECULAR BIOLOGY
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Abstract

The effects of extracts of ten plant species from Russia and five species from Vietnam on the growth and survival of ciliates Tetrahymena pyriformis were studied. T. pyriformis belongs to the subkingdom Protozoa, which also includes pathogens of protozoan infections. Extraction of dried plants was carried out with acidic and alkaline aqueous solutions, as well as with an aqueous ethanol. Various amounts of extracts were added to the ciliate cells, and the number of cells survived after incubation for 1 and 24 h was recorded. We found that our samples of several plants, including wormwood, harmala, and licorice, similarly to those studied earlier, exhibit antiprotozoal activity, which may indicate that the secondary metabolites are the same in plants from different regions. Using the ciliate T. pyriformis as a model organism, the presence of antiprotozoal activity in extracts of lilac, chondrilla, cinquefoil, hop, and elm was shown for the first time.

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Funding

This work was supported by the Russian Foundation for Basic Research (project no. 21-54-54005) and the Vietnamese Academy of Sciences and Technology (project no. QTRU01.15/21-22).

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Authors and Affiliations

  1. Mental Health Research Centre, Moscow, Russia

    E. G. Cheremnykh

  2. Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia

    A. V. Osipov, V. G. Starkov,  V. I. Tsetlin & Yu. N. Utkin

  3. Nguyen Tat Thanh University, Ho Chi Minh, Vietnam

    Nguyen Thi Thuy Trang

  4. Institute of Applied Materials Science, Vietnam Academy of Science and Technology, Ho Chi Minh, Vietnam

    Nguyen Cuu Khoa, Hoang Ngoc Anh & Le Tien Dung

Authors
  1. E. G. Cheremnykh
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  2. A. V. Osipov
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  3. V. G. Starkov
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  4. Nguyen Thi Thuy Trang
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  5. Nguyen Cuu Khoa
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  6. Hoang Ngoc Anh
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  7. Le Tien Dung
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  8. V. I. Tsetlin
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  9. Yu. N. Utkin
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Correspondence to Yu. N. Utkin.

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The authors declare that they have no conflicts of interest. The article does not contain any studies performed by any of the authors of this work and involving human participants or animals as objects.

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Translated by M. Batrukova

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Cheremnykh, E.G., Osipov, A.V., Starkov, V.G. et al. New Plant Species Showing Antiprotozoian Activity. Dokl Biochem Biophys 507, 334–339 (2022). https://doi.org/10.1134/S160767292234004X

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  • DOI: https://doi.org/10.1134/S160767292234004X

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