Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Research Article
  • Published:

Examination of G72 and D-amino-acid oxidase as genetic risk factors for schizophrenia and bipolar affective disorder

Molecular Psychiatry volume 9, pages 203–207 (2004)Cite this article

Abstract

A recent study has suggested that the brain-expressed genes for G72 and D-amino-acid oxidase (DAAO) exert an influence on susceptibility to schizophrenia. Our aim was to replicate this finding in German schizophrenic patients and to assess whether G72 and DAAO might also contribute to the development of bipolar affective disorder. We genotyped seven single-nucleotide polymorphisms (SNPs) in the G72 gene and three in the DAAO gene in 599 patients (299 schizophrenic, 300 bipolar) and 300 controls. At G72, individual SNPs and a four-marker haplotype were associated with schizophrenia. The most significant SNP as well as the haplotype were also associated with bipolar affective disorder (BPAD). DAAO was associated with schizophrenia, but not with BPAD. The association of variation at G72 with schizophrenia as well as BPAD provides molecular support for the hypothesis that these two major psychiatric disorders share some of their etiologic background.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Straub RE, Jiang Y, MacLean CJ, Ma Y, Webb BT, Myakishev MV . Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia. Am J Hum Genet 2002; 71: 337–348.

    CAS  PubMed  PubMed Central  Google Scholar 

  2. Schwab SG, Knapp M, Mondabon S, Hallmayer J, Borrmann-Hassenbach M, Albus M . Support for association of schizophrenia with genetic variation in the 6p22.3 gene, dysbindin, in sib-pair families with linkage and in an additional sample of triad families. Am J Hum Genet 2003; 72: 185–190.

    Article  CAS  PubMed  Google Scholar 

  3. Stefansson H, Sigurdsson E, Steinthorsdottir V, Bjornsdottir S, Sigmundsson T, Ghosh S . Neuregulin 1 and susceptibility to schizophrenia. Am J Hum Genet 2002; 71: 877–892.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Stefansson H, Sarginson J, Kong A, Yates P, Steinthorsdottir V, Gudfinnsson E . Association of neuregulin 1 with schizophrenia confirmed in a Scottish population. Am J Hum Genet 2003; 72: 83–87.

    Article  CAS  PubMed  Google Scholar 

  5. Chumakov I, Blumenfeld M, Guerassimenko O, Cavarec L, Palicio M, Abderrahim H . Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia. Proc Natl Acad Sci USA 2002; 99: 13675–13680.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Sklar P . Linkage analysis in psychiatric disorders: the emerging picture. Annu Rev Genomics Hum Genet 2002; 3: 371–413.

    Article  CAS  PubMed  Google Scholar 

  7. Maier W, Lichtermann D, Minges J, Hallmayer J, Heun R, Benkert O . Continuity and discontinuity of affective disorders and schizophrenia. Results of a controlled family study. Arch Gen Psychiatry 1993; 50: 871–883.

    Article  CAS  PubMed  Google Scholar 

  8. Dawson E, Parfitt L, Roberts Q, Daniels J, Lim L, Sham P . Linkage studies of bipolar disorder in the region of the Darier's disease gene on chromosome 12q23–24.1. Am J Med Genet 1995; 60: 94–102.

    Article  CAS  PubMed  Google Scholar 

  9. Jones I, Owen MJ, Craddock N . Further evidence of familial cosegregation of major affective disorder and Darier's disease. Mol Psychiatry 1999; 4: 73.

    Google Scholar 

  10. Detera-Wadleigh SD, Badner JA, Berrettini WH, Yoshikawa T, Goldin LR, Turner G . A high-density genome scan detects evidence for a bipolar-disorder susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2. Proc Natl Acad Sci USA 1999; 96: 5604–5609.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Kelsoe JR, Spence MA, Loetscher E, Foguet M, Sadovnick AD, Remick RA . A genome survey indicates a possible susceptibility locus for bipolar disorder on chromosome 22. Proc Natl Acad Sci USA 2001; 98: 585–590.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Hattori E, Liu C, Badner JA, Bonner TI, Christian SL, Maheshwari M . Polymorphisms at the G72/G30 gene locus, on 13q33, are associated with bipolar disorder in two independent pedigree series. Am J Hum Genet 2003; 72: 1131–1140.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Grigoroiu-Serbanescu M, Martinez M, Nöthen MM, Grinberg M, Sima D, Propping P et al . Different familial transmission patterns in bipolar I disorder with onset before and after age 25. Am J Med Genet 2001; 105: 765–773.

    Article  CAS  PubMed  Google Scholar 

  14. First MB, Spitzer RL, Gibbon M, Williams JBW . Structured Clinical Interview for DSM-IV Axis I Disorders, Patient edn. New York: Biometrics Research Department New York State Psychiatric Institute, 1997.

    Google Scholar 

  15. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 4th edn Washington, DC: American Psychiatric Association, 1994.

  16. Becker T, Knapp M . Maximum-likelihood estimation of haplotype frequencies in nuclear families. (submitted for publication).

  17. Devlin B, Risch N . A comparison of linkage disequilibrium measures for fine-scale mapping. Genomics 1995; 29: X311–322.

    Article  Google Scholar 

Download references

Acknowledgements

This study was supported by the National Genomic Network (NGFN) of the German Ministry of Education and Research, the SFB 400 of the German Research Council (DFG), the Fund for Scientific Research Flanders (FWO, Grants G.0425.02 and G0438.03), the Belgium Interuniversity Attraction Pole (IUAP ‘Molecular Genetics and Cell Biology’) and a Concerted Research Project (GOA) by the University of Antwerp. AVDB holds a predoctoral position with the Institute for the Promotion of Innovation by Science and Technology in Flanders (IWT). We thank Dr E Hattori for communicating primer sequences for SNPs rs1341402 and rs1935062.

Author information

Authors and Affiliations

  1. Institute of Human Genetics, University of Bonn, Germany

    J Schumacher, R Abon Jamra, J Freudenberg, A C J Otte & P Propping

  2. Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Germany

    T Becker

  3. Central Institute of Mental Health, Mannheim, Germany

    S Ohlraun & M Rietschel

  4. Department of Psychiatry, University of Bonn, Germany

    S Ohlraun, M Tullius, S Kovalenko, W Maier & M Rietschel

  5. Department of Medical Genetics, University of Antwerp, Belgium

    A Van Den Bogaert, M M Nöthen & S Cichon

Authors
  1. J Schumacher
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R Abon Jamra
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J Freudenberg
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. T Becker
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. S Ohlraun
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. A C J Otte
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. M Tullius
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. S Kovalenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. A Van Den Bogaert
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. W Maier
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. M Rietschel
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. P Propping
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. M M Nöthen
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. S Cichon
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to J Schumacher.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Schumacher, J., Abon Jamra, R., Freudenberg, J. et al. Examination of G72 and D-amino-acid oxidase as genetic risk factors for schizophrenia and bipolar affective disorder. Mol Psychiatry 9, 203–207 (2004). https://doi.org/10.1038/sj.mp.4001421

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.mp.4001421

Keywords

This article is cited by

Search

Advanced search

Quick links