Elsevier

Brain Research

Volume 1000, Issues 1–2, 12 March 2004, Pages 192-194
Brain Research

Short communication
c-fos antisense oligonucleotides increase firing rate of striatal neurons in the anaesthetized rat

https://doi.org/10.1016/j.brainres.2003.10.061Get rights and content

Abstract

Extracellular electrophysiological recordings were used to study the firing rate of striatal neurons before and up to 4 h after intrastriatal c-fos antisense oligonucleotide injections in urethane-anesthetized rats. A four-fold increase from baseline neuronal activity was observed between 1 and 3 h upon antisense treatment, but not after control oligonucleotide injections. We conclude that, under urethane anesthesia, which here does not affect c-fos expression in the striatum by itself, neuronal activity appears to be tonically suppressed by basal striatal c-fos expression.

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