Abstract
Objective
To compare the effectiveness and safety profile of LEEP (Loop Electrosurgical Excision Procedure) verses cryotherapy in the treatment of CIN.
Material and Method
Women with abnormal pap smears were subjected to VIA and VILLI followed by colposcopy. A total of 200 cases were included in this prospective study. Once the diagnosis of CIN was confirmed on histopathology, the women were subjected to either cryotherapy or LEEP randomly. They were follow up at 1, 6 and 12 months. At 12 months follow up, cervix was subjected to VIA, VILLI and colposcopy. Chi square test was used to analyze the data.
Observations
The efficacy of cryotherapy was found to be 88% and that of LEEP was 94% which is not significantly different. The overall cure rate of symptoms was 82 and 79% in cryosurgery and LEEP group, respectively.
Conclusion
Although LEEP was associated with higher cure rates but the difference is not significant statistically. Either method if used appropriately gives good results in treatment of CIN lesions, however, LEEP seems to have an edge over cryotherapy when used on severe lesions.
Similar content being viewed by others
References
Saraiya UB, Miniello G. Significance of human papilloma virus infection in cervical carcinogenesis. J Obstet Gynecol India. 2007;57:486–92.
Kerkar A, Rajendra A, Kulkarni YV. Screening for cervical cancer: an overview. J Obstet Gynecol India. 2006;56:115–22.
Dietsch E, Gibb H, Francis K. Abnormal pap test results and the rurality factor. Aust J Rural Health. 2003;11(2):50–6.
Pandey K, Bhagoliwal A. Cancer cervix—need for mass surveillance programme specially in rural areas. J Obstet Gynecol. 2005;55(5):436–9.
Ashrafunnessa, Mohammad K. Cervical intraepithelial neoplasia & its relationship with hormonal contraceptive methods. Bangladesh Med Res Counc Bull. 2008;34:33–8.
Parrazzani F, Chatenoud L, Vecchia LC, et al. Determinants of risk of invasive cervical cancer in young women. Br J Cancer. 1998;77(5):838–41.
Misra JS, Das V, Singh U, et al. Comparative risk assessment of age and parity in cervical carcinogenesis. J. Obstet Gynecol India. 2007;57(5):422–5.
Munoz N, Franceschi S, Bosetti C, et al. Role of parity & HPV in cervical cancer: the IARC multicentric case-control study. Lancet. 2002;159:1093–101.
Melissa S, Miller J, Masuk M, et al. Contraceptive & reproductive risk factor for cervical intra epithelial neoplasia in American Indian woman. Int J Epidemiol. 2000;29:983–98.
Rivoire WA, Monego HL, Reis RD, et al. Comparison of loop electrosurgical Conizatio with one or two passes in high grade cervical intraepithelial neoplasias. Gynecol Obstet Invest. 2009;67:228–35.
Dhaubhadel P, Vaidya A, Choudhary P. Early detection of precursors of cervical cancer with cervical cytology and visual inspection of cervix with acetic acid. J Nepal Med Assoc. 2008;47(170):71–6.
Chirenje ZM, Rusakaniko S, Akino V, et al. A randomised clinical trial of loop electrosurgical excision procedure (LEEP) versus cryotherapy in the treatment of cervical intraepithelial neoplasia. J obstet Gynaecol. 2001;21((5)):617–21.
Kehrli LD, Cordola DM. Cervical dysplasia recurrence rates among university women: cryosurgery compared with loop excisional electrical procedure. Northridge: California State University.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Singh, A., Arthur, B. & Agarwal, V. LEEP Verses Cryotherapy in CIN. J Obstet Gynecol India 61, 431–435 (2011). https://doi.org/10.1007/s13224-011-0048-1
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13224-011-0048-1