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Sinonasal DEK-rearranged Papillary Non-keratinizing Squamous Cell Carcinoma: Expanding the Emerging Entity

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Abstract

The newly emerging sinonasal carcinomas have demonstrated diverse morphologies and specific molecular mutations along with deviant clinical behavior from conventional counterparts. Also, many sinonasal malignancies turned to be SMARCB1/SMARCA4-deficient. Even with the morphological similarities between poorly differentiated (non) keratinizing sinonasal squamous cell carcinoma (SNSCC) from DEK::AFF2 SNSCC, the two lesions are not distinguishable using the surrogate immunohistochemical marker AFF2 or molecular testing for DEK::AFF2 mutation. We report a rare case of SMARCB1-retained DEK-rearranged papillary non-keratinizing SNSCC in a 53-year-old female, who presented with a polypoid mass corresponding to the left middle turbinate. The tumor and locoregional lymph nodes were surgically resected, followed by adjuvant radiotherapy.

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Virtual slides for H&E and immunohistochemical markers will be made available upon reasonable request.

References

  1. Andreasen S, Kiss K, Mikkelsen LH et al (2019) An update on head and neck cancer: new entities and their histopathology, molecular background, treatment, and outcome. APMIS 127:240–264. https://doi.org/10.1111/apm.12901

    Article  PubMed  Google Scholar 

  2. Storck K, Hadi UMd, Simpson R et al (2008) Sinonasal renal cell-like adenocarcinoma: a report on four patients. Head Neck Pathol 2:75–80. https://doi.org/10.1007/s12105-008-0047-4

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Agaimy A, Bishop JA (2021) SWI/SNF-deficient head and neck neoplasms: an overview. Semin Diagn Pathol 38:175–182

    Article  PubMed  Google Scholar 

  4. Agaimy A, Weichert W (2017) SMARCA4-deficient sinonasal carcinoma. Head Neck Pathol 11:541–545. https://doi.org/10.1007/s12105-017-0783-4

    Article  PubMed  PubMed Central  Google Scholar 

  5. Agaimy A, Fuchs F, Moskalev EA et al (2017) SMARCA4-deficient pulmonary adenocarcinoma: clinicopathological, immunohistochemical, and molecular characteristics of a novel aggressive neoplasm with a consistent TTF1neg/CK7pos/HepPar-1pos immunophenotype. Virchows Arch. https://doi.org/10.1007/s00428-017-2148-5

    Article  PubMed  Google Scholar 

  6. Herpel E, Rieker RJ, Dienemann H et al (2017) SMARCA4 and SMARCA2 deficiency in non–small cell lung cancer: immunohistochemical survey of 316 consecutive specimens. Ann Diagn Pathol. https://doi.org/10.1016/j.anndiagpath.2016.10.006

    Article  PubMed  Google Scholar 

  7. Agaimy A, Rau TT, Hartmann A, Stoehr R (2014) SMARCB1 (INI1)-negative rhabdoid carcinomas of the gastrointestinal tract: clinicopathologic and molecular study of a highly aggressive variant with literature review. Am J Surg Pathol. https://doi.org/10.1097/PAS.0000000000000173

    Article  PubMed  PubMed Central  Google Scholar 

  8. Shah AA, Jain D, Ababneh E et al (2020) SMARCB1 (INI-1)-deficient adenocarcinoma of the sinonasal tract: a potentially under-recognized form of sinonasal adenocarcinoma with pccasional Yolk Sac Tumor-Like features. Head Neck Pathol 14:465–472. https://doi.org/10.1007/s12105-019-01065-7

    Article  PubMed  Google Scholar 

  9. Kuo Y, Lewis JS, Truong T et al (2022) Nuclear expression of AFF2 C-terminus is a sensitive and specific ancillary marker for DEK::AFF2 carcinoma of the sinonasal tract. Mod Pathol 35:1587–1595. https://doi.org/10.1038/s41379-022-01117-4

    Article  CAS  PubMed  Google Scholar 

  10. Ruangritchankul K, Sandison A (2023) DEK::AFF2 fusion carcinomas of head and neck. Adv Anat Pathol 30:1–9. https://doi.org/10.1097/PAP.0000000000000376

    Article  CAS  Google Scholar 

  11. Rooper LM, Agaimy A, Dickson BC et al (2021) DEK-AFF2 Carcinoma of the Sinonasal Region and Skull Base: detailed clinicopathologic characterization of a distinctive entity. Am J Surg Pathol 45:1682–1693. https://doi.org/10.1097/PAS.0000000000001741

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, Hospital de Dénia, Ptda. Beniadlá, s/n, 0700, Denia, Alicante, Spain

    Juan B. Laforga

  2. Department of Pathology, Mansoura University, Mansoura, Egypt

    Bacem Abdullah

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  1. Juan B. Laforga
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  2. Bacem Abdullah
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Both authors have contributed equally to the manuscript.

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Correspondence to Bacem Abdullah.

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For the reported case study, pathology micrographs provided do not contain any identifying marks and are not accompanied by text that might identify the individual concerned.

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Laforga, J.B., Abdullah, B. Sinonasal DEK-rearranged Papillary Non-keratinizing Squamous Cell Carcinoma: Expanding the Emerging Entity. Indian J Otolaryngol Head Neck Surg 75, 3866–3870 (2023). https://doi.org/10.1007/s12070-023-03877-0

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