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Synthesis, crystal structures and DNA-binding properties of dinuclear complexes with macrocyclic ligands

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Abstract

Two symmetrical macrocyclic dinuclear complexes, [Cu2L1(ClO4)2(H2O)2][Cu2L1(H2O)2] (ClO4)2 (1) and [Cu2L2(ClO4)2] (2), (where H2L1 and H2L2 are the [2 + 2] condensation products of 1,3-diaminopropane with 2,6-diformyl-4-methylphenol and 2,6-diformyl-4-flurophenol, respectively), have been synthesized and characterized. The electronic and magnetic properties of the complexes were studied by cyclic voltammetry and magnetic susceptibility. There are strong antiferromagnetic couplings between the two copper(II) centers in both complexes. The strongly electron-withdrawing fluorine groups in H2L2 weaken the antiferromagnetic exchange, but make the metal centers more easily reduced than its analog H2L1. The interactions of the complexes with calf thymus DNA were studied by UV–Vis and CD spectroscopic techniques.

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Acknowledgments

We are thankful for the financial support from the National Nature Science Foundation of China (20971102), the Foundation of the Excellent Middle-Young Innovation Group of Education Department of Hubei Province (T200802), Nature Science Foundation of Hubei Province (2008CDB022) and the Foundation of the Key Laboratory for Green Chemical Process of Ministry of Education, Wuhan Institute of Technology (RGCT200804).

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Authors and Affiliations

  1. Key Laboratory for Green Chemical Process of Ministry of Education, Wuhan Institute of Technology, Wuhan, People’s Republic of China

    Qingrong Cheng, Hong Zhou & Zhiquan Pan

  2. School of Materials Science and Chemical Engineering, China University of Geosciences, Wuhan, People’s Republic of China

    Jinzhong Chen

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  1. Qingrong Cheng
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  2. Hong Zhou
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Correspondence to Hong Zhou.

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Cheng, Q., Zhou, H., Pan, Z. et al. Synthesis, crystal structures and DNA-binding properties of dinuclear complexes with macrocyclic ligands. Transition Met Chem 37, 407–414 (2012). https://doi.org/10.1007/s11243-012-9602-7

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