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Effects of sesamin on Aβ1-42-induced oxidative stress and LTP impairment in a rat model of Alzheimer's disease

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Abstract

The present study examined the protective effect of sesamin (Ses) on β-amyloid (Aβ)-induced long-term potentiation (LTP) impairment at the PP-DG synapses in male rats. Wistar rats were randomly assigned to seven groups: control, sham, Aβ; ICV Aβ1-42 microinjection, Ses, Aβ + Ses; first, ICV Aβ injections and then receiving Ses, Ses + Aβ: four weeks of pretreatment with Ses and then Aβ injection, and Ses + Aβ + Ses: pre (four weeks) and post (four weeks) treatment with Ses. Ses-treated groups received 30 mg/kg of Ses once a day by oral gavage for four weeks. After the treatment period, the animals were positioned in a stereotaxic device for surgery and field potential recording. The population spike (PS) amplitude and slope of excitatory postsynaptic potentials (EPSP) were evaluated in the DG region. Serum oxidative stress biomarkers (total oxidant status (TOS) and total antioxidant capacity (TAC)) were measured. Aβ impaired LTP induction at the PP-DG synapses evidenced by a decrease in EPSP slope and PS amplitude of LTP. In Aβ rats, Ses increased EPSP slope and PS amplitude of LTP in the DG granular cells. Also, an increase in TOS and a reduction in TAC caused by Aβ were significantly corrected by Ses. Ses could prevent Aβ-induced LTP impairment at the PP-DG synapses in male rats, which can be due to its preventive effects on oxidative stress.

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Data availability statements

The datasets generated and/or analyzed during this study are available from the corresponding author on reasonable request.

Data Availability

Data will be made available on request.

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Acknowledgements

The authors are grateful to the staff of the Neurophysiology Research Center, Hamadan University of Medical Sciences for supporting this study.

Funding

This research was carried out at the Hamadan University of Medical Sciences (Grant No.: 140010218738).

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Authors and Affiliations

  1. Department of Neuroscience, School of Science and Advanced Technologies in Medicine, Hamadan University of Medical Sciences, Shahid Fahmideh Street, Hamadan, Iran

    Amir Arabi, Seyed Asaad Karimi, Iraj Salehi & Alireza komaki

  2. Department of Pharmacology Toxicology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran

    Rasool Haddadi

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  1. Amir Arabi
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  2. Seyed Asaad Karimi
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Contributions

Each author has made substantial intellectual contributions to the design, implementation, and interpretation of studies described. A.A. conducted experiments, data acquisition and drafting the manuscript; S.A.K. and I.S. were responsible for administrative, technical and material support and critical revision of the manuscript for important intellectual content; R.H. contributed technical support and manuscript drafting. A.K. contributed to the study design and supervision, statistical analysis of data, writing and critical revision of the manuscript.

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Correspondence to Alireza komaki.

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Animal care processes were approved by the Veterinary Ethics Committee of the Hamadan University of Medical Science (Ethic code: IR.UMSHA.REC.1400.456) and were accomplished consistent with the Guidelines of the National Institutes of Health (NIH Publication 80–23, 1996).

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Arabi, A., Karimi, S.A., Salehi, I. et al. Effects of sesamin on Aβ1-42-induced oxidative stress and LTP impairment in a rat model of Alzheimer's disease. Metab Brain Dis 38, 1503–1511 (2023). https://doi.org/10.1007/s11011-023-01191-w

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