Abstract
Emerging evidence suggests that the gastrointestinal tract plays a crucial role in the pathophysiology of sepsis, a leading cause of mortality among patients admitted to the intensive care unit (ICU). Malvidin, belonging to the flavonoid family of compounds, exhibits a range of capabilities including anti-inflammatory and antioxidant properties. Studies have demonstrated that Malvidin exhibits a dose-dependent effect in mitigating sepsis-induced intestinal injury. The advantageous impact of Malvidin in safeguarding against sepsis-induced intestinal injury is associated with its capacity to counteract oxidative stress, inhibit cellular apoptosis, diminish the secretion of pro-inflammatory cytokines, and regulate the synthesis of inflammasomes. The findings indicate that Malvidin, a natural compound, exhibits protective effects on the gut by activating the nuclear factor erythroid 2-related factor 2/reactive oxygen species/NLRP3 inflammasome pathway. These results have significant implications for potential clinical applications and offer valuable insights into the treatment of sepsis-induced intestinal injury.
Data availability
Data will be made available on reasonable request.
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Acknowledgements
This study was supported by grants from the Basic Science (Natural Science) Research Project of Higher Education of Jiangsu Province (No. 21KJB230001), Open-end Funds of Jiangsu Key Laboratory of Marine Bioresources and Environment (No. SH20221203), and the Priority Academic Program Development of Jiangsu Higher Education Institutions of China.
Funding
Basic Science (Natural Science) Research Project of Higher Education of Jiangsu Province, No. 21KJB230001, Jingquan Dong, Open-end Funds of Jiangsu Key Laboratory of Marine Bioresources and Environment, No. SH20221203, Jingquan Dong, the 2022 Medical Research guiding Project of Jiangsu Provincial Health Commission, No. Z2022070, Jingquan Dong, the Priority Academic Program Development of Jiangsu Higher Education Institutions of China.
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GW and FM: research design, writing original draft, and editing. FM: conceptualization, software, formal analysis, and visualization. WZ, and YX: investigation and data curation. KP: methodology. YW and JD: data curation, resources, and project administration.
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Guanglu WANG, Fenfen Ma, Wei ZHANG, Yue XIN, Kaixin PING,Yan Wang, Jingquan DONG declare that they have no conflict of interest.
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The "Animal Welfare and Ethics Committee of Jiangsu Ocean University," the "Principles of Laboratory Animal Care" (NIH Publication No. 85–23, amended in 1985), and the NIPRD calibration protocols (NIPRD/05.03.05–1) were all rigorously adhered to in our animal investigations.
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Wang, G., Ma, F., Zhang, W. et al. Malvidin alleviates LPS-induced septic intestinal injury through the nuclear factor erythroid 2-related factor 2/reactive oxygen species/NLRP3 inflammasome pathway. Inflammopharmacol 32, 893–901 (2024). https://doi.org/10.1007/s10787-023-01378-8
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DOI: https://doi.org/10.1007/s10787-023-01378-8