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Different ELR (+) angiogenic CXC chemokine profiles in synovial fluid of patients with Behçet’s disease, familial Mediterranean fever, rheumatoid arthritis, and osteoarthritis

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Abstract

The aim of the present study was to determine synovial levels of ELR (+) CXC chemokines, known to attract mainly neutrophils to inflamed tissues by binding the neutrophil chemokine receptors CXCR1 and CXCR2 and promoting neovascularization in patients with various inflammatory disorders. The study group consisted of 14 patients with Behçet’s disease and nine with familial Mediterranean fever. Fourteen patients with rheumatoid arthritis and 16 with osteoarthritis served as controls. Synovial chemokine levels were measured by two-step sandwich enzyme-linked immunosorbent assay, and significant differences were found in the various chemokines studied. In addition to its angiogenic properties, increased synovial levels of interleukin-8 by attraction of more neutrophils to synovial fluids might also be responsible for the acute synovitis in patients with Behçet’s disease. However, the absence of chronic changes with the eventual development of pannus and erosions might result from relatively lower expression of interleukin-8 and the transient, short-lived nature of the arthritis observed in these patients.

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Authors and Affiliations

  1. Department of Rheumatology, Gülhane Military School of Medicine, Etlik, Ankara 06018, Turkey

    Hakan Erdem, Salih Pay, İsmail Şimşek & Ayhan Dinç

  2. Department of Biochemistry, Gülhane Military School of Medicine, Ankara, Turkey

    Muhittin Serdar

  3. Department of Immunology, Gülhane Military School of Medicine, Ankara, Turkey

    Uğur Muşabak & Aysel Pekel

  4. Department of Hydroclimatology, Gülhane Military School of Medicine, Ankara, Turkey

    Mustafa Turan

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  1. Hakan Erdem
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  2. Salih Pay
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  3. Muhittin Serdar
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  4. İsmail Şimşek
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  5. Ayhan Dinç
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  6. Uğur Muşabak
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Correspondence to Hakan Erdem.

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Erdem, H., Pay, S., Serdar, M. et al. Different ELR (+) angiogenic CXC chemokine profiles in synovial fluid of patients with Behçet’s disease, familial Mediterranean fever, rheumatoid arthritis, and osteoarthritis. Rheumatol Int 26, 162–167 (2005). https://doi.org/10.1007/s00296-004-0524-3

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  • DOI: https://doi.org/10.1007/s00296-004-0524-3

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