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Exploring RSM-CCD-optimized chitosan-/gelatin-based hybrid polymer network containing CPM–β-CD inclusion complexes as controlled drug delivery systems

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Abstract

The present work reported the synthesis of pH-responsive hybrid polymer network (HPN) of chitosan and gelatine by using glutaraldehyde as a cross-linker. Different reaction parameters like backbone ratio, amount of solvent, pH, the time, the temperature of reaction mixture and concentration of cross-linker were optimized with response surface methodology in order to maximize the percentage swelling. The maximum percentage swelling was obtained 530.48% under most optimized conditions of the ratio (1:1), pH (7) and cross-linker (0.241 mol/l). Poor loading of drug in traditional drug delivery is improved by incorporating preformed inclusion complex of chlorphenamine maleate (CPM) with β-cyclodextrin (1:1) under microwave conditions directly into the HPN matrix. Further, HPN matrix was used to investigate the in situ controlled release of CPM under different pH conditions at 37 °C. CPM release showed the best fit to the Peppas–Sahlin equation under all pH conditions at 37 °C. Thus, HPN prepared by using RSM design is a good device to deliver the CPM in a controlled manner.

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Abbreviations

CH:

Chitosan

GEL:

Gelatin

HPN:

Hybrid polymer network

GLA:

Glutaraldehyde

IC:

Inclusion complex

β-CD:

Beta-cyclodextrin

CPM:

Chlorphenamine maleate

IPN:

Interpenetrating network

IA:

In air

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Acknowledgements

One of the authors is highly grateful to MHRD for providing financial assistance to carry out research. The author is also thankful to Instrumentation Center, IIT Roorkee, Punjab University, Chandigarh, for different characterization of samples and DST-FIST for providing financial assistance for procurement of equipment like FTIR and UV–Vis spectrophotometer used in the characterization of the samples.

Funding

Funding was provided by MHRD [Grant No. 15520006 (Reg No.)].

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Authors and Affiliations

  1. Department of Chemistry, Dr. B. R. Ambedkar National Institute of Technology Jalandhar, Jalandhar, Punjab, 144011, India

    Kuljit Kaur & Rajeev Jindal

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  1. Kuljit Kaur
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  2. Rajeev Jindal
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Correspondence to Rajeev Jindal.

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Kaur, K., Jindal, R. Exploring RSM-CCD-optimized chitosan-/gelatin-based hybrid polymer network containing CPM–β-CD inclusion complexes as controlled drug delivery systems. Polym. Bull. 76, 3569–3592 (2019). https://doi.org/10.1007/s00289-018-2555-z

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