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Correlates of nephrolithiasis in US black women: data from the black women’s health study

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Abstract

Nephrolithiasis is a common urologic condition and a significant source of patient morbidity and healthcare expenditure. There are few epidemiologic studies of kidney stones focusing exclusively on Black women. We retrospectively assessed the prevalence and correlates of self-reported kidney stones within the Black Women’s Health Study (BWHS). Descriptive statistics and multivariable logistic regression models were used to explore factors associated with nephrolithiasis. As of the 2005 follow-up questionnaire, a cumulative total of 1063 women among 43,178 reported ever being diagnosed with kidney stones for a prevalence of 2.64%. Women with a history of nephrolithiasis were older, slightly heavier, and were more likely to have a comorbid condition (e.g., type-2 diabetes, gallstones), drink alcohol, and consume a Western-style diet. A history of gallstone disease was associated with an odds ratio (OR) of 3.59 (95% confidence interval (CI) 3.09–4.17). The OR for consuming ≥ 7 alcoholic beverages/week, compared to none was 0.61 (0.39–0.94), while the OR for high adherence to the Western diet, compared to low adherence was 1.53 (1.23–1.90). Our findings are consistent with previous studies of primarily white populations relating lifestyle-associated risk factors with nephrolithiasis. Despite their lower prevalence of kidney stones, it is important to focus on vulnerable populations such as Black women given their disproportionate burden of metabolic conditions (e.g., obesity, diabetes) related to kidney stone disease.

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Data availability

Data underlying the study cannot be made publicly available due to ethical concerns about patient confidentiality. Data will be made available to qualified researchers on request to BWHS@bu.edu.

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Funding

This work was supported by the National Institute of Cancer (Grant No. CA58420 and UM1CA164974) and the National Institute of Diabetes and Digestive and Kidney Diseases (Grant No. U01DK106786).

Author information

Authors and Affiliations

  1. Department of Urology, Thomas Jefferson University Hospital, Philadelphia, PA, USA

    Maria D’Amico

  2. Department of Urology, Boston Medical Center, Boston, MA, USA

    Shaun Wason

  3. Slone Epidemiology Center, Boston University School of Medicine, 72 East Concord Street, Boston, MA, 02118, USA

    Yvette C. Cozier

Authors
  1. Maria D’Amico
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  2. Shaun Wason
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  3. Yvette C. Cozier
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Contributions

All authors of this research manuscript have directly participated in the planning, execution or analysis of this study. Specifically, Drs. Cozier and Wason designed and conducted the research; Drs. Cozier and D’Amico conducted all data analysis. Dr. D’Amico drafted the manuscript and all authors contributed to the interpretation of the data and critically revised the manuscript. Dr. Cozier had full access to all the data in the study and will take responsibility for the integrity of the data and the accuracy of the data analysis. Drs. D’Amico, Wason, and Cozier read and approved the final manuscript.

Corresponding author

Correspondence to Yvette C. Cozier.

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The study protocol was approved by the Institutional Review Board of Boston University School of Medicine.

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BWHS participants indicate consent by completing and returning the questionnaires.

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D’Amico, M., Wason, S. & Cozier, Y.C. Correlates of nephrolithiasis in US black women: data from the black women’s health study. Urolithiasis 51, 29 (2023). https://doi.org/10.1007/s00240-022-01391-6

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