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Expression of CCX CKR in pulmonary sarcoidosis

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Abstract.

Objective

CCX CKR is a decoy chemokine receptor that specifically binds the chemokines CCL19, CCL25 and CCL21. CCL19 was previously found to be upregulated in pulmonary sarcoidosis. We have, therefore, investigated CCX CKR expression in this inflammatory disease.

Methods and results

CCX CKR mRNA was semiquantitated using RT-PCR in unseparated bronchoalveolar (BAL) cells from sarcoidosis patients (S, n = 29) and healthy control subjects (C, n = 9). CCX CKR transcripts were upregulated in patients (mean  ±  SEM); S, 0.82  ±  0.10; C, 0.44  ±  0.04; p  =  0.01; this upregulation paralleled the disease course as assessed by the chest radiographic stage (p  <  0.02). Immunocytochemistry localised the CCX CKR protein to ciliated bronchial cells. Flow cytometric fluorescent ligand uptake assay showed that these cells are able to internalize its ligand.

Conclusion

These observations implicate CCX CKR in the modulation of the inflammatory response in sarcoidosis.

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Authors and Affiliations

  1. Department of Immunology, Palacky University and Faculty Hospital Olomouc, I.P. Pavlova str. 6, 775 20, Olomouc, the Czech Republic

    E. Kriegova, A. Tsyrulnyk, A. Arakelyan, F. Mrazek, M. Ordeltova & M. Petrek

  2. Department of Respiratory Medicine, Palacky University and Faculty Hospital, Olomouc, the Czech Republic

    J. Zatloukal & V. Kolek

  3. Interstitial Lung Disease Unit, Royal Brompton Hospital, London, United Kingdom

    R. M. du Bois

  4. Laboratory of Environmental and Respiratory Pathology, Institute of Pathology, Medical University, Graz, Austria

    S. Petzmann & H. Popper

Authors
  1. E. Kriegova
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  2. A. Tsyrulnyk
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  3. A. Arakelyan
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  4. F. Mrazek
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  5. M. Ordeltova
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  6. S. Petzmann
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  7. J. Zatloukal
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  8. V. Kolek
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  9. R. M. du Bois
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  10. H. Popper
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  11. M. Petrek
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Corresponding author

Correspondence to M. Petrek.

Additional information

Received 2 February 2006; returned for revision 24 April 2006; accepted by M. Parnham and J. Skotnicki 9 May 2006

E. Kriegova, A. Tsyrulnyk, and A. Arakelyan contributed equally to this work

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Kriegova, E., Tsyrulnyk, A., Arakelyan, A. et al. Expression of CCX CKR in pulmonary sarcoidosis. Inflamm. res. 55, 441–445 (2006). https://doi.org/10.1007/s00011-006-6019-9

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  • DOI: https://doi.org/10.1007/s00011-006-6019-9

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